Abstract:

Objective To investigate the association between high density lipoprotein（HDL）and clinical outcomes of continuous ambulatory peritoneal dialysis（CAPD）patients. Methods The clinical data of patients re⁃ ceived continuous ambulatory peritoneal dialysis were followed up in the First Affiliated Hospital of Guangxi Medi⁃ cal University from January 2010 to January 2020. Patients were divided into the maintenance and withdrawal groups. Cox regression analysis was used to explore the association between HDL and clinical outcomes. Results A total of 433 patients were enrolled with 276 in the maintenance group and 157 in the withdrawal group，in which 70 were died，and 87 were transferred to hemodialysis. There were 229 patients with dyslipidemia（52.9%）. The median follow⁃up was 35.33（21.78，61.17）months. The median age of dialysis，serum albumin，total cholesterol （TC）and HDL in withdrawal group were lower than those in maintenance group. According to HDL level，patients were divided into Q1（> 2.17 mmol/L），Q2（1.04～2.17 mmol/L）and Q3（<1.04 mmol/L）groups. The PD drop⁃ out rate and all ⁃cause mortality in HDL ⁃Q3 group were significantly higher than those in HDL ⁃Q1 and HDL ⁃Q2 groups. Decreased HDL level was an independent risk factor for patients to drop out of PD（all P < 0.05）. Conclu⁃ sions Low HDL was an important risk factor affecting all⁃cause mortality and withdrawal in PD patients.

Key words: serum lipid,  , peritoneal dialysis,  , high?density lipoprotein, clinical outcome