人干扰素α-1b雾化联合布地奈德对呼吸道合胞病毒重症肺炎患儿血清CCL5、CCL11指标及临床疗效的影响

doi:10.3969/j.issn.1006-5725.2026.15.019

Abstract

Abstract:

Objective To investigate the effects of nebulized human interferon alpha-1b in combination with budesonide on the levels of serum chemokine ligand 5 （CCL5） and chemokine ligand 11 （CCL11） and the clinical efficacy in children with severe respiratory syncytial virus （RSV） pneumonia. Methods A total of 270 children with severe RSV pneumonia who were admitted to Ningxia Medical University General Hospital from March 2022 to February 2025 were prospectively included and randomly divided into a control group （n = 135） and an observation group （n = 135） using a random number table. Both groups received basic symptomatic treatment. Specifically， the control group received budesonide nebulization inhalation treatment， while the observation group received human interferon alpha-1b nebulization treatment on the basis of the treatment given to the control group. The improvement time of symptoms after treatment， serum CCL5 and CCL11 levels， Th1/Th2 immune balance indicators， airway remodeling and oxidative stress indicators， blood gas indicators， and adverse reactions before and after treatment were compared. Results The disappearance time of cough， wheezing， and lung rales in the observation group was shorter than that in the control group （P < 0.05）. After treatment， the serum levels of CCL5 and CCL11 in the observation group were lower than those in the control group （P < 0.05）. The levels of interleukin-4 （IL-4） in the observation group were lower than those in the control group， while the levels of interferon gamma （IFN-γ） and the IFN-γ/IL-4 ratio were higher than those in the control group （P < 0.05）. The observation group had lower levels of mucin 5AC （MUC5AC） and 8-hydroxydeoxyguanosine （8-OHdG） and higher levels of superoxide dismutase （SOD） compared to the control group （P < 0.05）. The arterial partial pressure of oxygen （PaO₂）， oxygenation index （PaO₂/FiO₂）， and blood oxygen saturation （SpO₂） in the observation group were higher than those in the control group （P < 0.05）. There was no significant difference in the total incidence of adverse reactions between the two groups （P > 0.05）. Conclusions The combination of human interferon alpha-1b and budesonide nebulized inhalation therapy can remarkably enhance the clinical symptoms in children suffering from severe RSV pneumonia. Through down-regulating the levels of serum CCL5 and CCL11， regulating the levels of Th1/Th2 immune index， inhibiting airway remodeling， lessening oxidative stress damage， and improving blood gas status， this combination therapy demonstrates high safety.

Key words: human interferon alpha-1b, budesonide, respiratory syncytial virus, severe pneumonia, child

CLC Number:

R725.6

Yinjuan ZHANG,Yaping YAN,Yanrong WANG. The effect of nebulization of human interferon alpha-1b combined with budesonide on serum CCL5 and CCL11 levels and clinical efficacy in children with severe respiratory syncytial virus pneumonia[J]. The Journal of Practical Medicine, 2026, 42(15): 2824-2831.

Figures/Tables 6

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References 25

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项目	对照组（n = 135）	观察组（n = 135）	Z/χ²/t值	P值
年龄［M（P₂₅，P₇₅）］/月	20（3，36）	20（4，35）	0.184	0.854
性别/［例（%）］			0.245	0.620
男	78	82
女	57	53
体质量/kg	10.23 ± 1.45	10.41 ± 1.39	1.041	0.299
病程/d	3.15 ± 1.08	3.17 ± 1.05	0.172	0.864
发热峰值/℃	38.13 ± 0.56	38.08 ± 0.59	0.714	0.476
心率/（次/min）	142.37 ± 12.24	143.12 ± 11.89	0.510	0.611
基础病史/例			0.232	0.630
有	22	25
无	113	110
WBC/（×10⁹·L^-1）	12.38 ± 3.19	12.41 ± 3.27	0.094	0.925
CRP/（mg/L）	15.27 ± 3.26	15.17 ± 3.19	0.245	0.807

组别	咳嗽消失时间	喘息消失时间	肺啰音消失时间
对照组（n = 135）	10.71 ± 1.42	4.56 ± 1.23	5.98 ± 1.31
观察组（n = 135）	9.02 ± 1.26	3.19 ± 0.87	4.26 ± 1.18
t值	10.343	10.636	11.321
P值	0.000	0.000	0.000

组别	CCL5/（ng/mL）		CCL11/（pg/mL）
组别	治疗前	治疗后	治疗前	治疗后
对照组（n = 135）	42.36 ± 6.59	29.76 ± 5.00^*	186.43 ± 26.49	113.58 ± 17.49^*
观察组（n = 135）	43.01 ± 5.96	21.24 ± 4.36^*	189.51 ± 24.86	85.49 ± 15.33^*
t值	0.850	14.899	0.985	14.030
P值	0.396	0.000	0.325	0.000

组别	IL-4/（pg/mL）		IFN-γ/（pg/mL）		IFN-γ/IL-4
组别	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组（n = 135）	32.86 ± 5.89	24.58 ± 5.26^*	18.46 ± 4.26	25.34 ± 5.11^*	0.57 ± 0.12	1.03 ± 0.21^*
观察组（n = 135）	33.10 ± 6.47	18.29 ± 4.09^*	18.33 ± 4.29	32.56 ± 6.34^*	0.55 ± 0.14	1.78 ± 0.32^*
t值	0.324	10.972	0.242	10.299	1.256	23.275
P值	0.460	0.000	0.809	0.000	0.210	0.000

组别	MUC5AC/（ng/mL）		8-OHdG/（ng/mL）		SOD/（U/mL）
组别	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组（n = 135）	156.71 ± 28.72	99.48 ± 17.03^*	3.44 ± 0.75	2.36 ± 0.54^*	56.54 ± 8.54	72.96 ± 11.23^*
观察组（n = 135）	159.90 ± 28.59	60.34 ± 15.49^*	3.54 ± 0.85	1.53 ± 0.41^*	56.72 ± 8.26	87.80 ± 11.92^*
t值	0.914	19.963	1.035	14.223	0.178	10.526
P值	0.361	0.000	0.301	0.00	0.859	0.000

The effect of nebulization of human interferon alpha-1b combined with budesonide on serum CCL5 and CCL11 levels and clinical efficacy in children with severe respiratory syncytial virus pneumonia

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组别	PaO?/mmHg		PaO?/FiO?		SpO?/%
组别	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组（n = 135）	60.68 ± 5.78	66.03 ± 5.10^*	248.95 ± 30.02	316.33 ± 25.91^*	90.18 ± 2.43	95.89 ± 1.99^*
观察组（n = 135）	60.44 ± 6.91	74.85 ± 6.27^*	248.10 ± 32.56	380.62 ± 31.09^*	90.44 ± 2.87	97.21 ± 2.01^*
t值	0.188	12.680	0.225	18.458	0.803	5.447
P值	0.851	0.000	0.822	0.000	0.423	0.000