Abstract:

Nowadays，the world is in a pandemic of novel coronavirus pneumonia（COVID⁃19）. Diabetes combined with COVID⁃19 has a high prevalence and fatality rate. Diabetes mellitus（DM）and COVID⁃19 interact with each other. SARS⁃CoV⁃2 infects islet cells through angiotensin⁃converting enzyme 2（ACE2）receptor to reduce insulin secretion. This virus can also cause cytokine storms and acute systemic inflammatory response， which can damage islet tissues and cause the rise of blood glucose concentration. Meanwhile，hyperglycemia promotes cell infection of SARS⁃CoV⁃2. Diabetic patients with immune dysfunction accelerate the progression of COVID⁃19. Metformin，DPP⁃4 inhibitors and statins have multiple effects to improve inflammation and immunoregulatory func⁃ tion，and should be treatment options for diabetic patients with COVID⁃19.DPP⁃4 has been found to be a potential binding target of SARS⁃CoV⁃2，

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