不可复性牙髓炎患者血清可溶性B7-H3、CX3趋化因子受体1水平变化及其临床意义

doi:10.3969/j.issn.1006-5725.2023.17.012

Abstract

Abstract:

Objective To detect the changes of soluble B7-H3 （sB7-H3） and CX3C chemokine receptor 1 （CX3CR1） levels in patients with irreducible pulpitis and explore their prognostic value. Methods A total of 104 patients with irreversible pulpitis involved in the study， including 52 cases of acute pulpitis and 52 cases of chronic pulpitis. According to the treatment results， 83 cases with good prognosis were assigned as one group and 21 cases with poor prognosis as another group. Meanwhile， another 101 healthy individuals who underwent physical examination during the same period were enrolled as the health group. Enzyme-linked immunosorbent assay was applied to detect serum levels of sB7-H3 and CX3CR1. Results The serum levels of sB7-H3 and CX3CR1 in the case group were higher than those in the healthy group （P < 0.05）. The serum levels of sB7-H3 and CX3CR1 in the acute pulpitis group were higher than those in the chronic pulpitis group （P < 0.05）. The serum levels of sB7-H3 and CX3CR1 in the poor prognosis group before and after treatment were higher than those in the good prognosis group （P < 0.05） and the serum levels of sB7-H3 and CX3CR1 were statistically significant different across different time points， between the groups and in terms of interactions （P < 0.05）. The proportion of patients with acute conditions in the poor prognosis group was higher than that in the good prognosis group （P < 0.05）. SB7-H3 and CX3CR1 were independent risk factors for the poor prognosis in the patients （P < 0.05）. Conclusion The levels of serum sB7-H3 and CX3CR1 in patients with irreversible pulpitis are elevated. They may become important indicators for evaluating the conditions and treatment effectiveness of irreversible pulpitis.

Key words: irreversible pulpitis, soluble B7-H3, CX3C chemokine receptor 1, prognosis

CLC Number:

R781.31

Yuanyuan YUAN,Lu PAN,Shaolan.. ZHOU. Changes in serum sB7⁃H3 and CX3CR1 levels in patients with irreversible pulpitis and their clinical significance[J]. The Journal of Practical Medicine, 2023, 39(17): 2221-2224.

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References 17

1	DONNERMEYER D， DAMMASCHKE T， LIPSKI M， et al. Effectiveness of diagnosing pulpitis： A systematic review［J］. Int Endod J， 2022， 10（1）：1-30.
2	RAMANI A， SANGWAN P， TEWARI S， et al. Comparative evaluation of complete and partial pulpotomy in mature permanent teeth with symptomatic irreversible pulpitis： A randomized clinical trial［J］. Int Endod J， 2022， 55（5）：430-440.
3	SHANG Y， LI Y， YANG Z， et al. Upregulation of TACAN in the trigeminal ganglion affects pain transduction in acute pulpitis［J］. Arch Oral Biol， 2022， 143（1）：1-13.
4	曹小彩，余增渊，王盈红，等. sB7-H3调控Th1细胞介导免疫应答对肺炎支原体肺炎患儿病情进展的影响［J］. 中华医院感染学杂志， 2022， 32（21）：3321-3325.
5	REN M， ZHANG J， DAI S， et al. CX3CR1 deficiency exacerbates immune-mediated hepatitis by increasing NF-κB-mediated cytokine production in macrophage and T cell［J］. Exp Biol Med， 2023， 248（2）：117-129.
6	GAO X W， HU H L， XIE M H， et al. CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization［J］. Exp Ther Med， 2023， 26（1）：359-369.
7	胡景团，刘友良. 口腔内科学［M］. 北京：科学出版社， 2014.
8	KOLI B， CHAWLA A， LOGANI A， et al. Combination of nonsurgical endodontic and vital pulp therapy for management of mature permanent mandibular molar teeth with symptomatic irreversible pulpitis and apical periodontitis［J］. J Endod， 2021， 47（3）：374-381.
9	BRODZIKOWSKA A， CIECHANOWSKA M， KOPKA M， et al. Role of lipopolysaccharide， derived from various bacterial species， in pulpitis-a systematic review［J］. Biomolecules， 2022， 12（1）：138-159.
10	DASTPAK M， GHODDUSI J， JAFARIAN A H， et al. Association between clinical symptoms and histological features of molars with acute pulpitis［J］. Iran Endod J， 2023， 18（2）：91-95.
11	KHORASANI M M Y， HASSANSHAHI G， BRODZIKOWSKA A， et al. Role（s） of cytokines in pulpitis： Latest evidence and therapeutic approaches［J］. Cytokine， 2020， 126（1）：1-8.
12	JI X， ZHANG L， YANG F， et al. Innate immune sensing of nucleic acid in endodontic infection［J］. Int Endod J， 2022， 55（12）：1335-1346.
13	SONG T， LI X， LIU L， et al. The effect of BMP9 on inflammation in the early stage of pulpitis［J］. J Appl Oral Sci， 2023， 31（1）：1-13.
14	LI Q L， WU Y Y， SUN H M， et al. The role of miR-29c/B7-H3/Th17 axis in children with Mycoplasma pneumoniae pneumonia［J］. Ital J Pediatr，2019， 45（1）：61-71.
15	WU P， WANG J. Changes and significance of serum sB7-H3 and cytokines in children with mycoplasma pneumonae pneumonia［J］. J Coll Physicians Surg Pak， 2020， 30（3）：268-271.
16	PAWELEC P， ZIEMKA-NALECZ M， SYPECKA J， et al. The impact of the CX3CL1/CX3CR1 axis in neurological disorders［J］. Cells， 2020， 9（10）：2277-2295.
17	荆忻，邵萍，李学莉. miR1433p通过调控CX3CL1/CX3CR1信号通路对脂多糖诱导肺泡上皮细胞损伤的影响［J］. 实用医学杂志， 2022， 38（21）：2649-2656.

组别	例数	sB7-H3（pg/L）	CX3CR1（ng/L）
健康组	101	5.06 ± 1.19	18.62 ± 4.57
病例组	104	6.59 ± 1.05	53.66 ± 7.62
t值	-	9.768	39.783
P值	-	< 0.001	< 0.001

病情	例数	sB7-H3（pg/L）	CX3CR1（ng/L）
慢性	52	5.62 ± 1.23	39.40 ± 6.52
急性	52	7.56 ± 1.31	67.92 ± 9.32
t值	-	7.785	18.081
P值	-	< 0.001	< 0.001

组别	例数	sB7-H3（pg/L）		CX3CR1（ng/L）
组别	例数	治疗前	治疗后	治疗前	治疗后
预后好组	83	6.06 ± 1.09	5.13 ± 1.18^a	48.72 ± 7.31	26.75 ± 5.17^a
预后差组	21	8.68 ± 1.20^b	6.84 ± 1.11^ab	77.14 ± 12.35^b	52.31 ± 8.24^ab
F值	-	F_时间=49.490、F_组间=120.971、F_交互=5.341		F_时间=340.954、F_组间=453.617、F_交互=12.734
P值	-	P_时间=0.000、P_组间=0.000、P_交互=0.022		P_时间=0.000、P_组间=0.000、P_交互=0.026

项目	例数	预后好组（n = 83）	预后差组（n = 21）	χ ² 值	P值
年龄				0.081	0.776
< 60岁	72	58（69.88）	14（66.67）
≥ 60岁	32	25（30.12）	7（33.33）
性别				0.287	0.592
女	50	41（49.40）	9（42.86）
男	54	42（50.60）	12（57.14）
文化程度				0.004	0.950
高中及以下	39	31（37.35）	8（38.10）
大学及以上	65	52（62.65）	13（61.90）
治疗后饮酒史				0.287	0.592
无	59	46（55.42）	13（61.90）
有	45	37（44.58）	8（38.10）
治疗后吸烟史				0.002	0.963
无	54	43（51.81）	11（52.38）
有	50	40（48.19）	10（47.62）
牙髓活力状态				1.451	0.228
活髓	86	71（85.54）	15（71.43）
死髓	18	12（14.46）	6（28.57）
高血压史				0.067	0.796
无	42	33（39.76）	9（42.86）
有	62	50（60.24）	12（57.14）
根尖周状态				0.738	0.390
无异常	88	72（86.75）	16（76.19）
暗影	16	11（13.25）	5（23.81）
病情				4.833	0.028
慢性	52	46（55.42）	6（28.57）
急性	52	37（44.58）	15（71.43）

影响因素	B	SE	Wald χ ²	OR	95%CI	P值
sB7-H3	1.023	0.320	10.216	2.781	1.485 ~ 5.207	0.001
CX3CR1	0.938	0.339	7.651	2.554	1.314 ~ 4.963	0.006
病情	0.103	0.214	0.234	1.109	0.729 ~ 1.687	0.629

Changes in serum sB7⁃H3 and CX3CR1 levels in patients with irreversible pulpitis and their clinical significance

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