Abstract:

Endometriosis（EM）is a common gynecological disease with an increasing incidence yearly. It mainly causes chronic pelvic pain and infertility. Due to the lack of“root cause”therapy for the etiology，the recur⁃ rence rate after conventional surgery is very high except radical surgery. Premenopausal patients need long ⁃term medication to prevent its recurrence. Moreover，there is no sensitive index for its early non⁃invasive diagnosis and monitoring of its early changes. Existing studies suggest that EM is closely related with microbial dysregulation in vivo. In this paper，we exploredthe possible ways by which microorganisms participate in the occurrence of EM. We concluded by reviewing literature that intestinal microorganisms may participate in the pathogenesis of EM byintervening lipid metabolism，estrogen metabolism and other ways，microorganisms and related metabolites may be used as early noninvasive diagnostic markers for EM，and finally，low fat and low carbon diet，consumingunsaturated fatty acids and probiotics supplementation may be a new approach to the prevention and control of EM.

Key words:

endometriosis, microbiome, metabolites, pathogenesis, treatment