Abstract:

Objective To analyze the clinical characteristics，laboratory examination indicators，glucocor⁃ ticoid therapy responsiveness of hospitalized patients with AECOPD with different blood eosinophil levels and to follow up for the prognosis. Methods A total of 124 COPD patients hospitalized in the Department of Respiratory and Critical Care Medicine，General Hospital of Tianjin Medical University from January 1 to December 31，2020， were concluded. The patients were divided into 3 groups according to the absolute value of blood eosinophil count within 24 hours of admission as the baseline level；the relevant data were analyzed and the curve was drawn. Results Blood eosinophil levels could assess the severity of disease progression in patients with AECOPD. Patients with EOS less than 100 cells/μL were more critically ill，but those with EOS greater than or equal to 100 cells/μL responded well to glucocorticoids，and long ⁃term ICS treatment can reduce the risk of recurrent severe exacerba⁃ tions in patients with EOS greater than 300 cells/μL. Conclusion The level of blood eosinophils helps to assess the degree of deterioration，benefit from ICS，and prognosis in AECOPD patients.

Key words:

eosinophil, chronic obstructive pulmonary disease, acute exacerbation, glucocorticoids, treatment