Abstract:

Objective To evaluate the efficacy of soybean powder in improving perimenopausal symptoms. Methods 97 perimenopausal patients were randomly selected from July 2016 to December 2019 to complete the perimenopausal symptom score. With the consent of the patients and the ethical approval of the hospital，they were allowed to take 50 grams of soybean powder a day for 90 days，and then complete the score again. The positive rate and score of perimenopausal symptoms before and after taking soybean powder were compared. The contents of urine metabolites estrol，dihydrodaidzein and o ⁃ demethylated Angolan red sandalwood were measured，and the correlation between metabolites and perimenopausal symptoms was analyzed. Result （1）the positive rate of perimenopausal symptoms after taking soybean powder was lower than that before taking soybean powder，and the difference was statistically significant（χ2 = 53.41，P < 0.001）.（2）The comprehensive score of perimenopausal symptoms after taking soybean powder was lower than that before taking soybean powder，and the difference was statistically significant（H = -8.52，P < 0.001）.（3）The dose of urinary metabolite estrol was negatively correlated with perimenopausal symptom weighted total score and insomnia（r = -0.23，P = 0.02）. Dihydrodaidzein was negatively correlated with palpitation（r = -0.27，P = 0.007）. O ⁃demethyl angola nobilin was negatively correlated with hot flashes，sweating，mood swings，and palpitations（r1 = -0.22，P1 = 0.03；r2 = -0.21，P2 = 0.04；r3 = -0.21，P3 = 0.04）. Conclusion Taking soybean powder is beneficial to reduce the occurrence and severity of perimenopausal symp⁃ toms. The content of estrol is related to perimenopausal symptoms and sleep quality. Dihydrodaidzein content is related to palpitation in patients. The content of o⁃demethylated Angolan rosewood is related to the symptoms of hot flashes，sweating，mood swings and palpitations.

Key words:

soybean flour, metabolites, perimenopause, symptom