Abstract:

Objective To explore the efficacy of sublingual immunotherapy（SLIT）with dermatophagoi⁃ des farinae drops in the treatment of mite allergen⁃induced allergic rhinitis（AR）at different treatment courses in children. Methods The data on 120 pediatric patients with mite allergen⁃induced AR，who had been treatment in the ENT department of Huazhong University of Science and Technology Union Shenzhen Hospital since 2013，were reviewed. Integral follow⁃up data was collected and a four⁃year course of treatment with SLIT was completed. A follow⁃up was started before therapy and every three months during the treatment. After therapy，total nasal symptom score（TNSS），total rhinitis medication scores（TRMS），visual analogue scale（VAS），and rhinoconjunctivitis quality of life questionnaire（RQLQ）scores were assessed；and adverse reactions were recorded. Results After one⁃year SLIT，TNSS，TRMS，VAS and RQLQ scores were significantly improved than the baselines（P < 0.05）； TNSS，TRMS，VAS and RQLQ scores，as compared with the one ⁃year therapy，were significantly improved two years after SLIT（P < 0.05）. VAS and RQLQ scores on the three⁃year therapy with SLIT were significantly improved than those on the two⁃year treatment with SLIT（P < 0.05）. TNSS，TRMS，VAS and RQLQ scores did not differ significantly between the three⁃year and the four⁃year therapies（P > 0.05）. There were no significant differences in the rate of adverse events among the one⁃year，two⁃year，three⁃year and four⁃year therapies（P > 0.05）. All the pediatric patients had no serious adverse reactions. Conclusions More than two years of SLIT，as compared with one year of therapy，has better effects for mite allergen⁃induced AR in children. VAS and RQLQ scores on the three⁃ year therapy with SLIT improve more markedly than those on the two⁃year therapy. Therefore，children should be treated for at least two years，and the 3⁃year therapy is the optimal course.

Key words:

mite allergen, dermatophagoides farinae drops, sublingual, allergic rhinitis, treatment course