Abstract:

Objective Ischemic stroke is one of the most important causes of neurological diseases and death in the world，but the current treatment scheme is limited. Methods Patients with ischemic stroke treated in our hospital from 2019 to 2021 were divided into control group and observation group，which were treated with trox⁃ erutin and troxerutin combined with high ⁃frequency electrotherapy respectively. The expression levels of miR ⁃ 137 and miR⁃155 were detected by RT⁃PCR in venous blood samples from patients before and after treatment. National Institutes of Health Stroke Scale（NIHSS）score and Barthel index（BI）statistics were performed in patients，and the Pearson correlation between the two was analyzed. Results After treatment，the expression level of miR⁃137 in peripheral blood of patients in the two groups increased，and the expression level of miR⁃155 decreased，while the change in observation group is significantly greater than that of controls. After treatment，the NIHSS score of the observation group was significantly lower than that of the control group，and the BI index was significantly higher than that of the control group（P < 0.05）. The results of correlation analysis showed that miR⁃137 expression level was negatively correlated with NIHSS score and positively correlated with BI index. MiR⁃155 expression levels were positively correlated with NIHSS score and negatively correlated with BI index. The effective rate of the observation group was higher than that of the control group，and the incidence of adverse reactions was lower than that in the control group. Conclusion Troxerutin combined with high frequency electrotherapy can improve nerve injury in patients with ischemic stroke.

Key words: troxerutin cerebroprotein hydrolysate,  , high frequency electrotherapy,  , ischemic stroke,  , miRNA