针灸对缺血性脑卒中康复患者免疫稳态及生活能力的影响

doi:10.3969/j.issn.1006-5725.2026.02.011

Abstract

Abstract:

Objective To investigate the value of acupuncture therapy in restoring immune homeostasis， reducing the levels of inflammatory markers， and improving the activities of daily living in patients recovering from ischemic stroke. Methods This research is a single-center， randomized controlled clinical trial. A total of 100 patients with ischemic stroke who were undergoing rehabilitation between August 2023 and January 2025 were enrolled. By using a random number table， the participants were randomly allocated to either a rehabilitation control group （n = 50）， which received integrated Chinese-Western rehabilitation therapy， or an acupuncture experimental group （n = 50）， which received acupuncture in addition to the standard integrated rehabilitation. The immune parameters （T， B， NK cell counts and CD4⁺/CD8⁺ ratio）， inflammatory markers， Barthel Index （BI）， and Fugl-Meyer Assessment （FMA） scores were compared before and after treatment. A cohort of 50 healthy individuals served as the healthy control group for assessing the baseline immune and inflammatory status. Results At baseline， the patient groups exhibited significant immune dysregulation when compared to the healthy control group. This was manifested by lower counts of total T cells， CD4⁺ cells， and CD8⁺ cells， as well as higher levels of B cells and NK cells （P < 0.05）. After the intervention， the acupuncture experimental group demonstrated a substantial increase in total T cells， CD4⁺ cells， and the CD4⁺/CD8⁺ ratio. Moreover， there was a more marked reduction in B and NK cell levels in the acupuncture experimental group compared to the rehabilitation control group. Inflammatory markers decreased in both groups after treatment， but the reduction amplitude was significantly greater in the acupuncture experimental group. Similarly， although both groups exhibited enhanced BI and FMA scores before and after treatments， the improvements were statistically more significant in the acupuncture experimental group （P < 0.05）. The acupuncture group showed significantly higher overall therapeutic efficacy compared to the rehabilitation control group， with overall therapeutic efficacy rates of 96.0% and 72.0%， respectively （P < 0.05）. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Adjunctive acupuncture significantly promotes immune rebalancing， alleviates inflammation， and enhances functional independence in rehabilitation patients with ischemic stroke.

Key words: ischemic stroke, acupuncture, peripheral blood lymphocyte subsets, inflammatory biomarkers, Barthel index, Fugl-Meyer assessment scale

CLC Number:

R246.1

Wei TAO,Shifeng LIANG,Zhinong SHI,Zhen LI,Lunshan WANG. Effects of acupuncture on immune homeostasis and functional recovery in ischemic stroke rehabilitation patients[J]. The Journal of Practical Medicine, 2026, 42(2): 255-265.

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References 38

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变量	健康对照组（n = 50）	康复对照组（n = 50）	针灸试验组（n = 50）	χ^２/F值	P值
性别				0.16	0.922
男	27（54.00）	28（56.00）	29（58.00）
女	23（46.00）	22（44.00）	21（42.00）
年龄［M（P₂₅，P₇₅）］/岁	68.50（62.00，77.75）	69.00（59.50，78.75）	71.50（65.25，79.00）	0.53	0.766
高血压				3.26	0.196
否	20（40.00）	29（58.00）	24（48.00）
是	30（60.00）	21（42.00）	26（52.00）
糖尿病				0.68	0.712
否	33（66.00）	31（62.00）	29（58.00）
是	17（34.00）	19（38.00）	21（42.00）
吸烟				1.36	0.506
否	35（70.00）	38（76.00）	40（80.00）
是	15（30.00）	12（24.00）	10（20.00）
饮酒				1.88	0.391
否	30（60.00）	36（72.00）	35（70.00）
是	20（40.00）	14（28.00）	15（30.00）

变量	健康对照组（n = 50）	康复对照组（n = 50）	针灸试验组（n = 50）	χ^２/F值	P值
总T/%	74.50（68.25，80.00）	50.00（37.00，66.75）	52.00（46.00，56.00）	73.98	< 0.001
CD4⁺/%	43.00（39.25，45.00）	24.50（17.25，37.75）	28.00（25.25，31.00）	54.99	< 0.001
CD8⁺/%	30.50（22.00，37.75）	22.50（17.00，27.75）	20.50（17.25，24.00）	20.66	< 0.001
CD4⁺/CD8⁺	1.42（1.13，2.19）	1.17（0.79，1.75）	1.35（1.13，1.73）	6.37	0.041
NK/%	14.00（10.00，18.00）	25.00（16.50，30.75）	26.00（22.00，29.00）	45.12	< 0.001
B/%	8.50（5.00，12.00）	21.00（18.00，23.75）	21.00（18.00，23.75）	88.98	< 0.001
WBC/（×10?·L ^-¹）	9.55（8.39，10.93）	19.43（17.34，21.62）	18.17（14.18，20.87）	89.82	< 0.001
CRP/（mg/L）	50.01（47.63，52.92）	129.40（91.00，141.30）	114.15（100.57，138.65）	89.78	< 0.001
TNF-α/（pg/L）	3.77（3.51，4.05）	6.34（4.49，8.10）	6.27（4.73，8.10）	45.92	< 0.001
IL-6/（pg/L）	36.56（34.12，38.32）	69.60（62.73，85.60）	67.94（55.08，79.86）	96.11	< 0.001

组别	基本恢复	明显进步	进步	稍进步	无变化	总有效率/%	χ2值	P值
康复对照组（n = 50）	6（12.00）	10（20.00）	10（20.00）	10（20.00）	14（28.00）	72.00	11.32	0.001
针灸试验组（n = 50）	15（30.00）	14（28.00）	10（20.00）	8（16.00）	3（6.00）	96.00

组别	针刺部位轻微疼痛	皮下出血（瘀斑）	胃肠道不适	肝功能异常（ALT 轻度升高）	总不良反应
康复对照组（n = 50）	0（0.00）	0（0.00）	5（10.00）	2（4.00）	7（14.00）
针灸试验组（n = 50）	4（8.00）	1（2.00）	3（6.00）	1（2.00）	9（18.00）
χ^２值	4.21	1.01	0.53	0.34	0.37
P值	0.040	0.315	0.467	0.560	0.543

Effects of acupuncture on immune homeostasis and functional recovery in ischemic stroke rehabilitation patients

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