TRPV1介导腹泻型肠易激综合征内脏高敏感的机制及针刺干预研究进展

doi:10.3969/j.issn.1006-5725.2025.07.023

Abstract

Abstract:

Transient Receptor Potential Vanilloid-1 （TRPV1） is a non-selective cation channel that is widely distributed in the sensory nerve fibers and non-neuronal cells of the gastrointestinal tract. It plays a critical role in mediating visceral hypersensitivity in Diarrhea-Predominant Irritable Bowel Syndrome （IBS-D）. Acupuncture activates TRPV1 receptors at the acupoint area， promoting the transformation of physical stimuli at the body surface into chemical signals within the body. This process coordinates with the nervous， endocrine， and immune systems to inhibit the expression of TRPV1 in the viscera through multiple mechanisms and pathways， demonstrating significant clinical efficacy in the treatment of IBS-D. This article reviews the mechanisms of TRPV1 in IBS-D visceral hypersensitivity， focusing on its relationship with the gut-brain axis imbalance， low-grade intestinal inflammation， and gut microbiota dysbiosis. It also summarizes the current research on acupuncture targeting TRPV1 in the treatment of IBS-D， aiming to provide scientific evidence and clinical insights for acupuncture therapy in functional diseases.

Key words: TRPV1, diarrhea-predominant irritable bowel syndrome, visceral hypersensitivity, mechanism, acupuncture

CLC Number:

R259

Yuanxin MA,Xiao MEI,Yunzheng WANG,Wei WANG. Research progress on the mechanism of TRPV1 in visceral hypersensitivity of IBS-D and acupuncture interventions[J]. The Journal of Practical Medicine, 2025, 41(7): 1084-1090.

Figures/Tables 1

References 62

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Research progress on the mechanism of TRPV1 in visceral hypersensitivity of IBS-D and acupuncture interventions

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