基于“原络配穴”针刺联合艾灸治疗脑梗死相关失眠的疗效及对血清下丘脑泌素-1、5羟色胺和脑电慢波的影响

doi:10.3969/j.issn.1006-5725.2025.08.024

Abstract

Abstract:

Objective To investigate the efficacy of acupuncture combined with moxibustion based on "Yuan?Luo Point Pairing" in treating insomnia related to cerebral infarction， and its effects on serum hypothalamic secretin-1 （Hcrt-1）， 5-hydroxytryptamine （5-HT）， and slow wave EEG. Methods 120 patients with cerebral infarction related insomnia admitted to our hospital from July 2022 to July 2024 were selected as the research subjects. They were randomly divided into an observation group and a control group， with 60 cases in each group， using a random number table method. The control group was treated with routine western medicine， and the observation group was treated with acupuncture combined with moxibustion based on "Yuan?Luo Point Pairing" on the basis of the control group. Compared the clinical efficacy， TCM syndrome score， sleep quality， serum Hcrt-1 and 5-HT， EEG slow wave indicators， and treatment safety of two groups. Results The effective rate of observation group was higher than control group （P < 0.05）. After treatment， the traditional Chinese medicine syndrome scores of observation group were lower than control group（P < 0.05）， including timidity， palpitations， shortness of breath， lazy speech， and no complexion. After treatment， the sleep quality indicators of the observation group， including sleep latency and rapid eye movement sleep were lower than those of the control group， while the total sleep time and sleep efficiency were higher than group control （P < 0.05）. After treatment， the serum Hcrt-1 and 5-HT levels of observation group were lower than group control （P < 0.05）. the slow waves in EEG， including θ and δ waves of observation group had lower frequencies than the control group and higher amplitudes than control group（P < 0.05）. Conclusions Acupuncture combined with moxibustion based on "Yuan?Luo Point Pairing" has significant therapeutic effects on insomnia related to cerebral infarction. It can reduce traditional Chinese medicine syndromes， improve sleep quality， lower serum Hcrt-1 and 5-HT levels， improve slow wave state of EEG in patients， and has good treatment safety.

Key words: insomnia related to cerebral infarction, Yuan?Luo Point Pairing, acupuncture, moxibustion, clinical efficacy, serum hypothalamic secretin-1, 5-hydroxytryptamine, slow wave of EEG

CLC Number:

R743

Hanqi YANG,Lingna. HE. The therapeutic effect of acupuncture combined with moxibustion on insomnia related to cerebral infarction based on the "Yuan⁃Luo Point Pairing" and its impact on serum Hcrt⁃1， 5⁃HT， and slow wave EEG[J]. The Journal of Practical Medicine, 2025, 41(8): 1253-1258.

Figures/Tables 6

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References 26

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组别	例数	显效	有效	无效	总有效率
观察组	55	30（54.55）	21（38.18）	4（7.27）	51（92.72）
对照组	54	24（43.64）	18（33.33）	12（22.22）	42（77.78）
χ² 值					4.862
P值					0.027

组别	例数	胆怯易惊		心悸不宁		气短懒言		面色无华
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	55	5.12 ± 0.68	1.65 ± 0.40^?	5.07 ± 0.78	1.74 ± 0.43^?	4.81 ± 0.83	1.86 ± 0.47^?	4.83 ± 0.91	1.98 ± 0.52^?
对照组	54	5.03 ± 0.72	1.98 ± 0.42^?	4.98 ± 0.79	2.09 ± 0.44^?	4.93 ± 0.86	2.29 ± 0.52^?	4.74 ± 0.94	2.35 ± 0.59^?
t值		0.490	4.201	0.598	4.200	0.741	4.531	0.508	3.475
P值		0.671	< 0.001	0.551	< 0.001	0.460	< 0.001	0.612	< 0.001

组别	例数	SL/min		REM/min		TST/h		SE/%
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	55	48.38 ± 6.92	29.65 ± 5.41^?	75.07 ± 8.78	58.74 ± 6.43^?	4.11 ± 0.73	5.96 ± 0.87^?	76.83 ± 7.76	87.98 ± 8.22^?
对照组	54	49.73 ± 6.84	34.76 ± 5.72^?	76.43 ± 8.14	64.09 ± 6.94^?	4.02 ± 0.75	5.29 ± 0.79^?	75.28 ± 7.71	81.35 ± 8.59^?
t值		1.024	4.793	0.838	4.176	0.635	4.207	1.046	4.117
P值		0.308	< 0.001	0.403	< 0.001	0.527	< 0.001	0.298	< 0.001

组别	例数	Hcrt-1		5-HT
组别	例数	治疗前	治疗后	治疗前	治疗后
观察组	55	88.23 ± 9.03	43.65 ± 6.01^?	125.07 ± 13.78	63.74 ± 6.98^?
对照组	54	87.17 ± 8.94	49.36 ± 6.32^?	123.28 ± 12.37	71.09 ± 7.84^?
t值		0.616	4.834	0.715	5.172
P值		0.539	< 0.001	0.477	< 0.001

组别	例数	θ波频率/Hz		θ波波幅/μV		δ波频率/Hz		δ波波幅/μV
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	55	9.82 ± 1.62	4.75 ± 1.02^?	55.07 ± 5.78	72.74 ± 7.83^?	8.81 ± 1.63	3.46 ± 0.77^?	68.83 ± 6.91	83.98 ± 8.52^?
对照组	54	9.65 ± 1.65	5.82 ± 1.24^?	54.41 ± 5.98	65.39 ± 7.24^?	8.65 ± 1.73	4.31 ± 0.85^?	67.24 ± 6.83	76.35 ± 8.09^?
t值		0.702	4.923	0.586	5.086	0.497	5.473	1.208	4.793
P值		0.484	< 0.001	0.559	< 0.001	0.620	< 0.001	0.229	< 0.001

The therapeutic effect of acupuncture combined with moxibustion on insomnia related to cerebral infarction based on the "Yuan⁃Luo Point Pairing" and its impact on serum Hcrt⁃1， 5⁃HT， and slow wave EEG

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组别	例数	头晕乏力	口干	食欲减退	局部刺痛	总发生率
观察组	55	2（3.64）	2（3.64）	1（1.82）	1（1.82）	6（10.91）
对照组	54	2（3.70）	1（1.85）	1（1.85）	0（0.00）	4（7.41）
χ² 值						0.401
P值						0.527

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