糖酵解代谢重编程在脓毒症急性肾损伤中的作用机制及治疗研究进展

doi:10.3969/j.issn.1006-5725.2026.14.019

Abstract

Abstract:

Septic acute kidney injury （SAKI）， a common and severe complication among sepsis patients， is characterized by a complex pathogenesis， a high morbidity rate， and a high mortality rate. In recent years， the role of metabolic reprogramming in the onset and development of diseases has drawn growing attention. As a crucial part of metabolic reprogramming， glycolytic metabolic reprogramming plays a significant role in the development and advancement of SAKI. This article reviews the research progress regarding the concept of glycolytic metabolic reprogramming， the mechanisms behind glycolytic metabolic reprogramming in SAKI， its regulatory impacts on SAKI， and SAKI treatment strategies based on glycolytic metabolic reprogramming. The purpose of this review is to thoroughly explore the pathogenesis of SAKI and offer potential targets for its clinical treatment.

Key words: septic acute kidney injury, metabolic reprogramming, glycolysis, mechanism, treatment strategy

CLC Number:

R692

Jiajia GOU,Ziyou TIAN,Zhu LI,Lili TANG,Gong ZHANG,Dongrui HE,Xiaoyue LI. Research progress on the mechanism and treatment of glycolytic metabolic reprogramming in septic acute kidney injury[J]. The Journal of Practical Medicine, 2026, 42(14): 2657-2664.

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References 58

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Research progress on the mechanism and treatment of glycolytic metabolic reprogramming in septic acute kidney injury

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