Abstract:

Objective To investigate the role of serum calcium binding protein S100A12 in severity assessment and prognosis of adult community ⁃ acquired pneumonia （community acquired pneumonia，CAP）. Methods Through a retrospective study，adult CAP patients hospitalized in the Department of Respiratory and Critical Medicine of the Affiliated Hospital of Southwest Medical University from December 2019 to October 2020 were taken as the case group，and the physical examiners of our hospital were taken as the control group. CAP patients were divided into severe pneumonia group（SCAP group）and non⁃severe pneumonia group（NSCAP group）. The differences of general information，basic medical history，invasive mechanical ventilation rate，ICU hospital⁃ ization rate，30⁃day survival rate，serum inflammatory markers between patients and healthy people and patients with different severity were compared. The patients were divided into death and survival group according to the prog⁃ nosis 30 days after admission. The differences of invasive mechanical ventilation rate and RICU hospitalization rate were compared. Univariate and multivariate logistic regression were used to study the influencing factors and inde⁃ pendent factors of death in adult CAP patients. The sensitivity，specificity and area under the curve of S100A12， CRP，SAA and PCT in predicting 30⁃day death of CAP patients were evaluated by subject working characteristic curve. Results A total of 138 cases were included in the study，including 23 cases in SCAP group，85 cases in ease，cardiovascular disease，invasive mechanical ventilation rate and ICU hospitalization rate. WBC，NLR， SAA，CRP，S100A12 and PCT in CAP group were higher than those in the control group；SAA，CRP，S100A12 and PCT in SCAP group were higher than those in NSCAP group；the 30⁃day survival rate in NSCAP group was higher than that in SCAP group. Univariate and multivariate logistic regression analysis showed that serum S100A12，SAA，CRP and PCT were independent influencing factors for predicting 30⁃day death in adult patients with CAP. S100A12 has the largest area under the 30⁃day death curve. Conclusion Serum S100A12 has high clinical value in evaluating the severity and prognosis of adult patients with CAP.

Key words:

S100A12, PCT, CRP, SAA, community acquired pneumonia in adults