Abstract:

Objective To investigate the effect of dexemetomidine combined with transverse abdominal plane block（TAPB）on postoperative gastrointestinal function in patients with laparoscopic colorectal surgery. Methods Eighty⁃two patients with selected laparoscopic colorectal surgery were randomly divided into DM + TAPB （study group）and saline（control group）in equal number. I⁃FEED scores at different postoperative time points， postoperative gastrointestinal dysfunction（POGD）occurrence，inflammatory factor level and recovery indicators were observed and compared between the two groups. Results （1）The I⁃FEED scores of the study group were lower than those of the control group at 24，48，72 and 96 h，respectively（P < 0.05）.（2）The incidences of POGD and PONV in the study group significantly lower than those of the control group，respectively（7.32% vs. 34.15%；19.51% vs. 48.78%，P < 0.05）.（3）The dose of intraoperative refentanyl by pump injection in the study group，the VAS scores and the number of postoperative analgesic compressions at 24，48 and 72 h were significantly smaller than in the control group（P < 0.05）.（4）The time of first defecation time，first oral feeding and first off⁃bed activity of the study group was significantly shorter than that of the control group（P < 0.05）.（5）The levels of CRP，TNF⁃α in 1 d I and 3 d IL⁃1β after treatment were significantly lower after treatment than in the control group（P < 0.05）. Conclusion Dex⁃ emetomidine combined with TAPB can effectively prevent the occurrence of POGD in patients having undergone laparoscopic colorectal surgery，accelerate their recovery，and provide effective strategies for POGD treatment.

Key words:

laparoscopic surgery, postoperative gastrointestinal dysfunction, dexmedetomidine, transverse abdominal plane block