Abstract:

Objective To explore the therapeutic effect of Erxiao decoction（Xiaoqinglong decoction and Xiaochaihu decoction）on allergic rhinitis（AR）in patients with lung qi deficiency cold patten and the role of regulatory cells（Tregs）related factors. Methods A total of 64 patients were randomly assigned into observation group（n = 32）and control group（n = 32）. The observation group was treated with Erxiao decoction，and the control group was treated with Loratadine tablets. After 28 days of treatment，the symptom score and serum trans⁃ forming growth factor including transforming growth factor⁃β，TGF⁃β，Interleukin⁃10（IL⁃10），interleukin⁃17（IL⁃ 17）content and quality of life were observed. Results The scores of sneezing，nasal itching and nasal congestion in the observation group were significantly lower than those in the control group（P < 0.05）. In the observation group，the levels of TGF⁃β in serum were significantly higher than those in the control group，IL⁃10 was signifi⁃ cantly higher than that of the control group（P < 0.05），and IL⁃17 was significantly lower than that of the control group（P < 0.05）. The rhinoconjunctivitis quality of life scale（RQLQ score）of the observation group was signifi⁃ cantly better than that of the control group（P < 0.05）. Conclusion Erxiao decoction could relieve the symptoms of AR and increase the serum TGF⁃β and IL⁃10. It is worthy of further study on its mechanism and long⁃term efficacy.

Key words:

allergic rhinitis, Xiaochaihu decoction, Xiaoqinglong decoction, Treg, randomized , controlled trial ,