Abstract:

Objective To study the clinical effect of modified Qibaisan combined with Q ⁃switched laser on chloasma of qi stagnation and blood stasis type via investigating its effect on malondialdehyde（MDA），lipid peroxide（LPO）and superoxide dismutase（SOD）in serum. Methods One hundred and twenty⁃six patients were randomly divided into treatment groups，control group 1 and 2 using the random digital table，treated with modified Qibaisan combined with Q⁃switched laser treatment，Q⁃switched laser alone and modified Qibaisan alone all for three treatment courses，one month as one course，respectively. At the end of the courses，the three groups were compared in terms of the curative effect. Results The skin lesions in treatment group were significantly improved，with the effective rate of 92.8%（39/42），while the effective rates of control groups 1 and 2 was 64.2%（27/42）and 71.4% （30/42），respectively. The differences in the effective rate between the three groups were statistically significant （P < 0.01）. The serum MDA/LPO of treatment group was significantly lower than that of control group 1 or 2，and the SOD was significantly increased（P < 0.01）. Conclusion Modified Qibaisan combined with Q ⁃ switched laser is more effective in treatment of patients with chloasma，and it is worthy of clinical application

Key words:

modified Qibaisan； Q ? switched laser； chloasma；malondialdehyde； lipid peroxide； superoxide dismutase

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