The Journal of Practical Medicine ›› 2022, Vol. 38 ›› Issue (18): 2284-2288.doi: 10.3969/j.issn.1006⁃5725.2022.18.007

• Clinical Advances • Previous Articles     Next Articles

The Helicobacter pylori BabA in gastric cancer：Current research advances 

YU Yang*，WANG Na，WANG Bofang，LI Yumin，CHEN Hao.    

  1. Department of Tumor Surgery，Lanzhou University Second Hospital，the Second Clinical Medical College of Lanzhou University，Lanzhou 730030，China；*Key Laboratory of Digestive System Tumors of Gansu Province，Lanzhou University Second Hospital，Lanzhou 730030，China 

  • Online:2022-09-25 Published:2022-09-25
  • Contact: CHEN Hao E⁃mail：ery_chenh@lzu.edu.cn；LI Yumin E⁃mail：liym@lzu.edu.cn
  • Supported by:

    国家自然科学基金（编号：31770537，82160129）；甘肃 省教育厅教育揭榜挂帅项目（编号：2021jyjbgs⁃02）；甘肃省科技重大 专项（编号：20ZD7FA003⁃1）；甘肃省重点人才项目（编号：2019RCXM020）； 兰州市城关区科技计划项目（编号：2019RCCX0034）

Abstract:

Infection of Helicobacter pylori（H.pylori）has become one of the intractable problems in the field of public health. It was identified asan association with many gastrointestinal diseases. Specially，its associa⁃ tion with gastric cancer that has been confirmed by substantial evidence.At present ，the studies that attend to explore the pathogenic mechanism of Hp mainly focus on the protein of virulence factor. As a newly identified virulence factor，the blood group antigen ⁃binding adhesion（BabA）has obtained a great attention on its roles for Hp to induce the occurrence and development of gastric cancer. This paper will comprehensively review the structure and function of BabA，its expression regulation，gastric cancer⁃promoting roles and clinical application，aiming to provide direction for developing new strategies in preventing and treating gastric cancer.

Key words:

stomach neoplasms, Helicobacter pylori, BabA, LewisB, risk factor