Abstract:

Objective To observe the efficacy of hyperbaric oxygen combined with oxiracetam in the treatment of chemotherapy ⁃ related cognitive impairment（CRCI）in patients with cervical cancer. Methods The patients with CRCI treated in our hospital from February 2019 to July 2021 were randomly assigned to a hyperbaric oxygen group or a control group. The control group received oxiracetam and inhalation of high⁃pressure air as placebo， whereas the hyperbaric oxygen group received oxiracetam plus hyperbaric oxygen. The Hopkins Verbal Learning Test ⁃Revised（HVLT ⁃R）and the Trail Making Test（TMT）were observed before，at the moment of treatment completion，and months 1 and 3 after treatment；MRI diffusion tensor imaging（DTI）was performed before and after treatment，the relevant laboratory indexes were collected before and after treatment in both groups. Results In the aspect of HVLT and TMT at different time points，the total HVLT score was higher and the total length of TMT was better in the hyperbaric oxygen group than in the control group at week 4 after treatment， months 1 and 3 after treatment completion（P < 0.05）. In terms of DTI，the FA values in the right sagittal stratum， bilateral cingulum，inferior fronto⁃occipital fasciculus，left superior longitudinal fasciculus，and splenium of corpus callosum were higher in the hyperbaric oxygen group than in the control group（P < 0.05）. For related laboratory indexes，levels of NSE，GFAP，and BDNF in the hyperbaric oxygen group were superior to those in the control group（P < 0.05）. Conclusions Hyperbaric oxygen combined with oxiracetam for CRCI in patients with cervical cancer can effectively improve cognitive impairment and imaging and laboratory indexes，showing a marked short⁃ and long⁃term efficacy.

Key words:

hyperbaric oxygen, oxiracetam, cervical cancer, chemotherapy?related cognitive impair? ment, diffusion tensor imaging