Abstract:

Objective Retention enema is a simple and effective method for preventing and treating radia⁃ tion proctitis（RP），while there is no standard regimen. This study aims to investigate the effectiveness of recombi⁃ nant human epidermal growth factor derivative for external use combined with smectite powder administrated by retention enema for the prevention of RP in cervical cancer patients. Method Fifty⁃nine patients with cervical cancer treated with radical radiotherapy were collected and randomly divided into control group（n = 28）and enema group（n = 31）. The enema group was given recombinant human epidermal growth factor derivative for external use combined with smectite powder by retention enema，while the control group did not receive enema administration. Results Gastrointestinal adverse reaction of the two groups was similar with grade 0⁃2，and there was no statistical difference between two groups（U = 429.5，P = 0.939）in acute PR. In terms of chronic PR，the sub⁃item score and total score of Vienna Rectoscopy Score（VRS）showed that there were more patients with mainly mild adverse events（grade 0 ~ 1）in enema group，while there were significantly more patients with moderate adverse events （grade 2 ~ 3）in the control group. Capillary telangiectasia（U = 262.5，P = 0.003），mucosal hyperemia（U = 256， P = 0.002）and VRS total score（U = 256，P = 0.002）were statistically different in the two groups. Conclusion Recombinant human epidermal growth factor derivative for external use combined with smectite powder administrat⁃ ing by retention enema could reduce the incidence and severity of chronic PR in patients with radical radiotherapy for cervical cancer.

Key words:

human epidermal growth factor, smectite powder, retention enema, cervical cancer, radiation proctitis