Abstract:

Objective To investigate the clinical characteristics and prognosis of patients weighing ≤ 10 kgin pediatric intensive care unit treated with continuous renal replacement therapy. Methods The patients weighing≤ 10 kg in pediatric intensive care unit treated from January 2010 to December 2019 were retrospectively analyzed.According to the clinical outcome，the patients were divided into survival group（n = 38）and non⁃survival group（n = 40），clinical characteristics and prognosis of patients were analyzed. Results This study included 78 cases，it was found that the proportion of regional citrate anticoagulation in the survival group was higher（92.1% vs. 70%，P = 0.029）；the CRRT initiation time was shorter in the survival group（calculated from the time of PICU admis⁃sion to CRRT initiation），the median time of the survival group was 18.6 hours，while the median time of the non⁃survival group was 66.5 hours（P = 0.002）；the fluid overload（FO%）of the survivors was lower when CRRT wasinitiated（1.9% vs. 8.6%，P = 0.001）. Multivariate logistic regression analysis showed PRISM Ⅲ score ，FO% andCRRT initiation time > 24 h were risk factors for the prognosis of patients in this group（OR = 1.120，1.109，3.912，P < 0.05）. Conclusion In our cohort，the prognosis of patients weighing ≤ 10 kg treated with continuous renalreplacement therapy was associated with FO%，PRISM Ⅲ score and CRRT initiation time.

Key words:

continuous renal replacement therapy, pediatric, prognosis analysis