Abstract:

As a new type of immunotherapy，Chimeric antigen receptor T cell therapy has become a hot spot in tumor field in recent years. The CD19 CAR ⁃T cell therapy achieved significant results particularly in the treatment of refractory and recurrent hematologic malignancies. However，the treatment is accompanied by signifi⁃ cant toxicities，the most widely reported being cytokine release syndrome（CRS）and neurotoxicity. While the true characteristics and mechanisms of cardiotoxicity remain unclear. This article summarizes the current acquaintance with cardiotoxicity of CD19 CAR⁃T cell therapy by introducing its mechanisms，clinical manifestation，prevention and treatment advances，aiming to minimize the risk of cardioascular complications，make more cancer patients benefit from the potential life⁃saving treatment.

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