实用医学杂志 ›› 2023, Vol. 39 ›› Issue (8): 1058-1062.doi: 10.3969/j.issn.1006⁃5725.2023.08.024

• 综述 • 上一篇    下一篇

冷冻消融联合免疫治疗在非小细胞肺癌治疗中的应用进展 

吴凯怡 吕学东 何海艳 陈金亮    

  1. 南通大学第二附属医院呼吸与危重症医学科(江苏南通 226001
  • 出版日期:2023-04-25 发布日期:2023-04-25
  • 通讯作者: 吕学东 E⁃mail:xuedonglv@126.com
  • 基金资助:
    江苏省科技项目(编号:BK20191207)

Progress in the application of cryoablation combined with immunotherapy in the treatment of NSCLC 

WU Kaiyi,LÜ Xuedong,HE Haiyan,CHEN Jinliang.    

  1. Department of Respiratory Medicine,the Second Affiliated Hospital of Nantong University,Nantong 226001,China
  • Online:2023-04-25 Published:2023-04-25
  • Contact: LÜ Xuedong E⁃mail:xuedonglv@126.com

摘要:

冷冻消融在非小细胞肺癌(non⁃small cell lung cancer,NSCLC)的治疗中除了通过低温使肿瘤 细胞脱水、破裂、坏死外,还可通过产生抗肿瘤免疫应答来发挥作用的。而近年来免疫治疗在 NSCLC 的治 疗方面效果显著。那么冷冻消融和免疫治疗在 NSCLC 治疗方面是否具有协同作用呢?本文就冷冻治疗、 免疫治疗及两种联合治疗在NSCLC 治疗中的应用进展作一综述。

关键词: 非小细胞肺癌, 冷冻消融, 免疫疗法, 联合免疫治疗

Abstract:

Cryoablation plays an important role in the treatment of non⁃small cell lung cancer in addition to dehydrating,rupturing and necrotizing tumour cells at low temperature,but also by generating anti⁃tumour immune responses. In recent years,immunotherapy has been effective in the treatment of NSCLC. So is there a synergistic effect between cryoablation and immunotherapy in NSCLC treatment? This article reviews the application of cryo⁃ therapy,immunotherapy and combination therapy in the treatment of NSCLC. 

Key words: non?small cell lung cancer, cryoablation, immunotherapy, combined immunotherapy

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