关键词:

CAR?T 免疫疗法, 胰腺癌, 靶点, 挑战, 联合治疗

Abstract:

Pancreatic canceris a highly malignant tumor，and its incidence has been increasing year byyear. There is currently a lack of particularly good screening，detection and treatment approach. Therefore，it′surgent to develop and find new effective and safe treatments for pancreatic cancer. In recent years，chimeric antigenreceptor T⁃cell immunotherapy（CAR⁃T）has made a major breakthrough in cancer treatment.As one of the effectivetreatment modalities for malignant tumors，the effect of CAR⁃T cell therapy can last for several years，tending tolong ⁃term anti ⁃tumor memory，and can effectively prevent recurrence. The technology is advancing rapidly，withnew advances occurring almost on a monthly basis，and eradication of pancreatic cancer may be substantiallyimproved. This article provides a brief overview of the basic components of CAR⁃T，the popular targets for pancreaticcancer and the main challenges they face，and summarizes the recent new advances on CAR⁃T research and thedirection of problem solving to provide research ideas for the subsequent treatment of pancreatic cancer.

Key words: chimeric antigen receptor T?cell immunotherapy,  , pancreatic cancer,  , target,  , challenge, combination therapy