实用医学杂志 ›› 2021, Vol. 37 ›› Issue (22): 2893-2897.doi: 10.3969/j.issn.1006⁃5725.2021.22.013

• 临床研究 • 上一篇    下一篇

结直肠癌NO.253淋巴结转移的危险因素分析

张建锋1 高相鑫1 武雪亮2 马洪庆1 胡旭华1 孟泽松1 张鹏飞3 唐宇杰4 王贵英3   

  1. 1 河北医科大学第四医院外二科(石家庄 050011);2 河北北方学院附属第一医院普通外科(河北张家口 075061);3 河北医科大学第三医院胃肠外科(石家庄 050051);4 河北医科大学研究生学院(石家庄 050017)

  • 出版日期:2021-11-25 发布日期:2021-11-25
  • 通讯作者: 王贵英 E⁃mail:13932186739@139.com
  • 基金资助:
    河北省医学科学研究重点课题计划(编号:20210134)

Analysis of risk factors for No.253 lymph node metastasis in colorectal cancer patients

ZHANG Jianfeng*, GAO Xiangxin,WU Xueliang,MA Hongqing,HU Xuhua,MENG Zesong,ZHANG Pengfei,TANG Yujie,WANG Guiying.   

  1. The Second Department of General Surgery,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China

  • Online:2021-11-25 Published:2021-11-25
  • Contact: WANG Guiying E⁃mail:13932186739@139.com​
  • Supported by:


摘要:

目的 探讨结直肠癌 NO.253 淋巴结转移的危险因素,为临床决策 NO.253 淋巴结清扫提供 参考。方法 采用回顾性研究方法,收集于 2017 9 月至 2019 4 月期间在河北医科大学第四医院外二科住院并行根治术的 205 例结直肠癌患者资料,选取可能影响 NO.253 淋巴结转移的临床病理因素进 行危险因素分析。结果 单因素分析显示,肿瘤距肛缘距离、术前血清癌胚抗原(CEA)和糖类抗原 19⁃9 (CA19⁃9)水平、T 分期、脉管瘤栓、神经受侵与 NO.253 淋巴结转移相关(P<0.05);多因素 logistic 回归分 析显示,脉管瘤栓是 NO.253 淋巴结转移的独立危险因素(OR=8.506,95%CI:1.841 ~ 39.302)。结论 管瘤栓是结直肠癌患者 NO.253 淋巴结转移的独立危险因素,是选择性 NO.253 淋巴结清扫的重要参 考因素。

关键词: 结直肠癌,  , NO.253淋巴结,  , 危险因素

Abstract:

Objective To explore the risk factors related to No.253 lymph node metastasis,in order to provide reference for No.253 lymph node dissection. Methods The data of 205 patients with colorectal cancer who underwent radical resection in our department from September 2017 to April 2019 was retrospectively analyzed. The clinicopathological factors that may affect lymph node metastasis of No.253 were selected for risk factor analysis. Results Univariate analysis data showed that No.253 lymph node metastasis was significantly related to the distance from the tumor to the anal margin,preoperative serum CEA,preoperative serum CA19⁃9,T stage,vascular tumor thrombus and nerve invasion(P<0.05). Multivariate Logistic regression analysis results demonstrated that vascular tumor thrombus[OR=8.506,95%CI(1.841,39.302)]was an independent risk factor for No.253 lymph node metastasis. Conclusion Vascular tumor thrombus is an independent risk factor for No.253 lymph node metas⁃ tasis. It could be an important reference factor for selective No.253 lymph node dissection.

Key words: colorectal cancer,  , No.253 lymph node,  , risk factors