Ovarian cancer represents a significant threat to women's health globally， with particularly high recurrence and mortality rates in China's context of gynecological malignancies. The effectiveness of traditional therapeutic approaches for advanced and recurrent ovarian cancer remains quite limited. However， recent studies have highlighted the substantial success of targeted therapies in managing ovarian cancer. This paper delves into both national and international research on ovarian cancer's targeted treatments， examining their mechanisms， applications， current landscape， and the challenges they face. It aims to offer innovative perspectives and directions for ovarian cancer treatment.

Overweight and obesity have emerged as a significant public health concern globally. While factors such as genetics， diet， and physical activity are insufficient to fully account for the rise in overweight and obesity， recent studies have indicated a link between environmental pollutants and the development of obesity. Microplastics， a novel type of environmental pollutant， are pervasive in various environmental media and daily life， entering organisms through multiple pathways including the digestive tract， respiratory tract， skin， among others. Evidence from studies has revealed the presence of microplastics in human tissues， organs， and biological samples， suggesting potential health risks to humans. This review outlines the pathways and distribution of microplastics within the human body while summarizing current research progress in relation to obesity. This article aims to raise awareness within society regarding the detrimental effects of microplastics and provide a theoretical foundation for medical professionals addressing public health issues.

Objective To explore the effect and mechanism of berberine combined with curcumin on atherosclerosis （AS） by mediating M1 macrophages polarization. Methods M1-type macrophages were obtained from mouse mononuclear macrophages （RAW264.7） induced by lipopolysaccharide （LPS， 100 ng/mL） and interferon （IFN）-γ （20 ng/mL）. A cell model was established. The cells were divided into a control group， model group， berberine group， curcumin group and berberine plus curcumin group. Concentrations of berberine and curcumin were detected by CCK-8 assay. The expression levels of M1-type macrophage markers iNOS， TNF-α， CXCL9 and p-STAT6/STAT6 in macrophage supernatant were detected by ELISA. Levels of iNOS， TNF-α and CXCL9 mRNA were detected by RT-PCR. Levels of iNOS， STAT6 and p-STAT6 proteins in each group were detected by Western blot. After down-regulation of STAT6 level by siRNA technology， expression of p-STAT6 protein was detected by Western blot. Expression levels of iNOS， TNF-α， CXCL9 and p-STAT6 were detected by ELISA. Results In the polarization of M1 macrophages induced by LPS and IFN-γ， berberine （25 μmol/L） and curcumin （20 μmol/L） were the best concentrations as compared with other drug concentration groups， and neither alone nor combined use could significantly inhibit the viability of RAW264.7 cells （P < 0.05）. As compared with the normal group， iNOS， TNF-α and CXCL9 mRNA and protein levels were increased in the model group， while P-STAT6/STAT6 levels were decreased， with statistical differences （P < 0.05）. As compared with the model group， iNOS， TNF-α and CXCL9 mRNA and protein levels in the berberine group， curcumin group， and berberine plus curcumin group were decreased， while P-STAT6 /STAT6 levels were increased， and the changes were more obvious in berberine plus curcumin group， with statistical difference （P < 0.05）. After transfection of STAT6 siRNA in M1 macrophages in the berberine plus curcumin group， P-STAT6 levels were down-regulated， while expressions of iNOS， TNF-α and CXCL9 were up-regulated， with statistical differences （P < 0.05）. Conclusions Both berberine and curcumin can inhibit the activity of M1-type macrophages and reduce inflammatory response. The action of berberine combined with curcumin is more advantageous than that of either drug alone， which may be the main mechanism of action through activation of STAT6.

Objective The objective of this study was to establish a mouse model of allergic rhinoconjunctivitis and investigate the role of the NLRP3 signaling pathway in allergic rhinoconjunctivitis. Methods Thirty-three female C57 mice （SPF） were randomLy divided into 3 groups： the control group， the experimental group， and the NLRP3^-/- group. On days 0， 4， 7， 14， and 21， the experimental group and NLRP3^-/- group received a 0.2 mL intraperitoneal injection of medicine containing OVA （100 μg） and adjuvant Al（OH）₃ （4 mg）， respectively. After an interval of 3 days， each eye and nose were dosed with 10 μL of 5% OVA for five consecutive days a week to induce allergic symptoms. During sensitization and excitation stages， the control group was replaced with an equivalent amount of PBS. Ocular and nasal symptoms were observed and scored. The levels of OVA-specific IgE， IL-4， IL-17， and IL-18 in serum were measured using ELISA， while changes in palpebral conjunctiva and nasal mucosa were assessed by hematoxylin-eosin staining. The expression of NLRP3 mRNA in conjunctival tissue and nasal mucosa was determined using real-time PCR analysis. Statistical analysis was performed using SPSS17.0 software with P < 0.05 considered as statistically significant difference. Results The experimental group and NLRP3^-/- group exhibited induced nasal and ocular allergic symptoms. In the experimental group， the duration of nasal allergy symptoms was （10.500 ± 1.080） days， while the duration of eye allergy symptoms was （20.300 ± 2.058） days. In the NLRP3^-/- group， the duration of nasal allergy symptoms was （13.400 ± 1.955） days， and for eye allergy symptoms it was （20.900 ± 2.132） days. The duration of nasal allergies in the NLRP3^-/- group significantly exceeded that in the experimental group （P < 0.05）， whereas there were no significant differences observed in eye allergy durations between these two groups （P > 0.05）. Levels of OVA-specific IgE， IL-4， and IL-17 were significantly higher in both the experimental and NLRP3^-/- groups compared to those in the control group （P < 0.05）. Additionally， serum IL-18 content increased significantly in the experimental group when compared with both control and NLRP3^-/- groups （P < 0.05）. Conjunctival tissue lesions as well as nasal mucosa damage were evident in both experimental and NLRP3^-/- groups. mRNA expression levels of NLRP3 within conjunctival tissue and nasal mucosa from the experimental group showed a significant increase when compared to those from both control and NLRP3^-/- groups（P < 0.05）. Conclusion Allergic rhinoconjunctivitis pathogenesis is influenced by various factors； however， the involvement of NLPR3 signaling pathway promotes its development.

Objective This study aimed to investigate the role and mechanism of atractylenolide I in inhibiting XPOT proliferation and invasion in gastric cancer cells. Methods This study included exploration of XPOT expression in gastric cancer tissues， analysis of gene expression data from GC patients in TCGA and GEO databases， as well as various cellular assays to detect the ability of cancer cells to proliferate， migrate， and invade. Protein expression levels of XPOT， SKP2， CyclinA， and P27 mRNA were also detected by qPCR and Western Blot. Results Analysis confirmed that XPOT was highly expressed in gastric cancer tissues， indicating a poor prognosis. In vitro studies revealed that AT-1 inhibits the proliferation and invasion ability of GC cells； XPOT down-regulation also inhibits these abilities. Furthermore， AT-1 down-regulates the expression of XPOT which then regulates SKP2， P27， and CyclinA - ultimately inhibiting the proliferation and invasion of gastric cancer cells through the regulation of the XPOT pathway. Conclusion The overexpression of XPOT in gastric cancer tissues can indicate a poor prognosis. Atractylenolide I down-regulates the XPOT-regulated ubiquitination-proteasome pathway to inhibit proliferation and invasion of gastric cancer cells.

Objective This study aimed to investigate the neuroprotective effect of microglia polarization mediated by Raf kinase inhibitor protein （RKIP） intracerebral hemorrhage （ICH） model. Methods Forty-eight adult male Sprague-Dawley （SD） rats were randomly divided into three groups：the Sham + Vector group，the ICH + Vector group， and the ICH + RKIP group， with 16 rats in each group. The collagenase ICH model was established in ICH+Vector group and ICH + RKIP group. Before operation and 1， 3， 5，and 7 days after operation， 8 animals in each group were tested for behavior. Apoptosis of neurons was detected by flow cytometry. Seven days after ICH， the expressions of RKIP， p-p65， and TRAF6 around hematoma were analyzed by protein blot. Results Compared with ICH + Vector group， rats in ICH + RKIP group need less time to find the platform， spend longer time in the target quadrant， and significantly reduce the times of crossing the platform （P < 0.05）. The number of Nissl corpuscles in ICH + RKIP group was significantly higher than that in ICH + Vector group （P < 0.05）. In addition， the number of neuronal apoptosis in ICH + RKIP group was significantly lower than that in ICH + Vector group （P < 0.05）. Compared with Sham group， rats receiving ICH showed a gradual decrease in RKIP expression， and reached the lowest value on the 7th day （P < 0.05）. Seven days after ICH， the expression of RKIP protein in hematoma of rats in ICH + RKIP group was significantly higher than that in ICH + Vector group （P < 0.05）， and the expression of p-p65 and TRAF6 protein was significantly lower than that in ICH + Vector group （P < 0.05）. Compared with ICH + Vector group， the number of iNOS + Ibal1+ cells in ICH + RKIP group decreased significantly （P < 0.05）， while the number of Arg-1 + Ibal1+ cells increased significantly （P < 0.05）. Conclusion Up-regulation of RKIP promotes functional recovery after ICH， and its mechanism involves inhibiting TRAF6/NF-κB signaling pathway.

Objective To explore the effect of leukocyte-and platelet-rich fibrin （L-PRF） as a capping agent in the modulation of inflammation in rat dental pulp. Methods The rat model of pulpitis was established by lipopolysaccharide（LPS）. A total of 30 Sprague-Dawley rats were randomly divided into five groups： Normal control group， Model group， iRoot BP PLUS group， L-PRF group， iRoot BP PLUS+ L-PRF group. Samples were collected on the 14th day after pulp capping. Micro-CT scans， HE and Masson staining，qRT-PCR assays were performed to observe pulp tissue inflammatory and hard tissue formation. Results Micro-CT results： no hard tissue formation was seen in the LPS group， plaque calculus was seen in the L-PRF group， and a more complete calcified bridge was seen at the perforation of the pulp in the BP and combined groups； HE and Masson staining results： the LPS group had the most severe inflammation and no hard tissue formation； the combined group had the least inflammation and the most complete and continuous hard tissue formation， and there was a statistical difference between the two groups（P < 0.01）； There was no statistical difference in the degree of inflammatory reaction and hard tissue formation between the BP group and the combined group （P > 0.05）；qRT-PCR results： the relative expression levels of TNF-α， IL-1β， and IL-6 mRNA in the pulp tissues of all experimental groups were reduced compared with those of the LPS group， but the differences between the L-PRF and LPS groups were not statistically significant （P > 0.05）. Conclusion The combination of L-PRF and iRoot BP PLUS as a composite pulp capping material can be used for the repair of dental pulp tissue and the regulation of inflammation in dental pulpitis in rats.

Objective To establish a simple model for arteriosclerosis （AS） screening to provide a viable tool for the timely identification of AS risk among residents aged 40 ~ 65 years. Methods Data were obtained from the Sleep and Chronic Diseases Program in Fuquan City. The original dataset was divided into a training subset and a validation subset （80%：20%）. LASSO and logistic regression models were used to screen variables， perform multivariate regression analyses. Internal validation was performed using the Bootstrap method. Nomogram Plot was constructed， and risk score thresholds were determined based on ROC curves to classify high-risk populations. Results RS Model was established to include age， gender， napping， sleep efficiency， sleep disorders， hypertension and diabetes， with AUC = 74.80% and a model risk score threshold = 84.20. PHC Model was established to include age， gender， napping， sleep efficiency， systolic blood pressure， fasting blood glucose， and pulse variables， with AUC = 82.80% and a risk score threshold of 78.00. Decision curves showed that both models performed well in terms of calibration and actual benefits for health management. Conclusion The two AS screening models exhibit acceptable accuracy and differentiation. Therefore， it can be applied in residents' self-health management and in primary care organizations' screening work in a large scale.

Objective To investigate the effect of mechanical thrombectomy using Solitaire stent combined with dual antiplatelet therapy （DAPT） on limb function and vascular reocclusion in patients with acute cerebral infarction. Methods A total of 134 patients with acute cerebral infarction who received treatment in our hospital from February 2020 to August 2023 were selected as samples. According to whether the patients regularly took aspirin and clopidogrel every day one week before surgery， they were divided into observation group（taking the medications）and control group （without taking medications）， with 67 cases in each. The control group was given mechanical thrombectomy， and the observation group was treated with DAPT combined with mechanical thrombectomy. Outcomes measured included revascularization one week after treatment， and neurological and limb function assessment using NIHSS and FMA scale at baseline， 1 day， 1 week， and 1 month after treatment. Brain hemodynamics （CVR， Qmean， and Vmean） and thrombosis markers （TXB2， CD62P， and 6-keto-PGF1α） were evaluated pre-treatment and one month after treatment. Vascular reocclusion three months after treatment and its correlation with hemodynamics and thrombosis factors were analyzed. Results After treatment， higher revascularization rate， FMA score， Qmean， Vmean， and 6-keto-PGF1α level， and lower NIHSS score， CVR， TXB2， and CD62P level were found in the observation group （P < 0.05）. The incidence of vascular reocclusion was also lower in the observation group. Logistic analysis indicated that brain hemodynamic indicators and the level of thrombosis-related factors influenced vascular reocclusion occurrence （P < 0.05）. Conclusion Mechanical thrombectomy using Solitaire stent combined with DAPT helps the recovery of limb function in patients with acute cerebral infarction and reduces the risk of vascular reocclusion.

Objective To investigate the application value of prognostic nutritional index and urea/creatinine ratio in nutritional status assessment for patients with esophageal cancer undergoing radiotherapy and chemotherapy. Methods A total of 138 patients with esophageal cancer who received radiotherapy and chemotherapy were screened. NRS 2002 nutritional screening was used as the standard. Prognostic nutritional index （PNI） and urea/creatinine ratio （UCR） were used to evaluate the malnutrition of patients with esophageal cancer. ROC curve was used to evaluate and compare the diagnostic efficacy of different nutritional screening tools. Results The biochemical and hematological indexes of patients with esophageal cancer showed certain characteristics， in which the levels of urea， creatinine， UCR， ALB， PALB， TP， TC， TG， HDL and LDL all fluctuated within the normal range. In terms of nutritional risk screening， the NRS 2002 score identified nutritional risk in 57.97% of patients， while the PNI and UCR predicted nutritional risk in 31.16% and 40.58% of patients， respectively. Consistency test showed that the Kappa value of PNI and NRS 2002 scores was 0.460 （P < 0.05）， and the Kappa value of UCR and NRS 2002 scores was 0.522 （P < 0.05）， indicating that there was a certain correlation between them and NRS 2002 scores in nutritional risk screening. Correlation analysis showed that NRS 2002 score was significantly correlated with UCR， ALB， PALB， PBL， Cr， HDL and TP （P < 0.05）， while PNI was significantly correlated with ALB， PALB， PBL， Cr， HDL， TP and UREA （P < 0.05）. There were significant correlations between UCR and PALB， UREA and Cr （P < 0.05）. Logistic univariate regression analysis further confirmed these correlations and revealed that malnutrition was negatively correlated with albumin， prealbumin， total protein， lymphocytes， creatinine and BMI， and positively correlated with urea. However， multivariate regression analysis did not find any statistical difference between these related factors and the two objective evaluation measures. The results of diagnostic efficacy evaluation showed that the area under ROC curve of PNI and UCR evaluation to predict esophageal cancer malnutrition was 0.779 and 0.736， respectively， with statistical significance （P < 0.001）. Among them， UCR showed higher sensitivity and PNI showed higher specificity， but there was no significant difference in diagnostic value between them. Conclusion PNI and UCR as nutritional assessment tools have certain application value in the nutritional risk screening of patients with esophageal cancer， but their consistency with NRS 2002 score needs to be improved. When assessing the nutritional status of patients， a combination of various indicators and methods should be used to achieve more accurate diagnostic results.

Objective To investigate the values of systemic inflammatory response index （SIRI）， systemic immunoinflammatory index （SII）， neutrophil count/lymphocyte count （NLR）， platelet count/lymphocyte count （PLR） and lymphocyte count/monocyte count （LMR） in prediction of the severity of acute pancreatitis （AP） at early stage. Methods The clinical data on 666 AP patients admitted to the department of hepatobiliary surgery， the First Affiliated Hospital of Anhui University of Science and Technology， from January 2020 to November 2023 were retrospectively analyzed. The patients were divided into a mild group （MAP group， mild acute pancreatitis） and a non-mild group （non-MAP group， including moderate to severe acute pancreatitis）. Blood routine and biochemical indicators were collected at admission and 24 hours after admission. The differences in SIRI， SII， NLR， PLR and LMR between the two groups were compared， so were the values of these five indexes in prediction of non-MAP. Results Of the 666 AP patients， 507 were in the MAP group and 159 in the non-MAP group. In the non-MAP group， C-reactive protein （CRP）， SIRI， SII， and NLR were higher than those in the MAP group 24 hours after admission， while LMR was lower than that in the MAP group， and the differences were statistically significant （P < 0.05）. CRP （HR = 1.008， 95%CI： 1.004 ~ 1.012， P < 0.05） and SIRI （HR = 1.216， 95%CI： 1.029 ~ 1.436， P < 0.05） were identified as the risk factors for the severity of AP. The ROC curve showed that the AUC and sensitivity of SIRI for predicting non-MAP 24 hours after admission were 0.718 and 75.00%， respectively， higher than those of SII， CRP， NLR， and LMR. Both SIRI and CRP had AUC values greater than 0.7， and the combined AUC was 0.788 （0.738 ~ 0.837）， the sensitivity was 86.00% and the specificity was 81.44%. Conclusions SIRI can be used as a predictor of disease severity in early AP patients， and combined with CRP can improve the predictive value.

Objective To analyze the clinical characteristics of pulmonary tuberculosis patients complicated with infection of Nocardia farcinica aiming to improve the diagnosis and treatment the disease. Methods The clinical data of 22 cases of pulmonary tuberculosis complicated with Nocardia farcinica infection admitted to Guangzhou Chest Hospital from June 2020 to December 2023 were collected and the clinical manifestations， imaging， laboratory tests， treatment process， and disease outcomes were retrospectively analyzed. Results Among the 22 patients， there were 13 males and 9 females， aged 20 ~ 86 years， with a median age of 52 years. Common clinical manifestations included cough （22/22）， sputum （21/22）， and underlying diseases （13/22）. One case was positive for cerebrospinal fluid culture， and 21 cases were positive for sputum culture. The culture period was 5 ~ 26 days， with a median culture period of 18 days. The imaging manifestations were mainly plaques， plaques and cavities， and the lesions were spread in both lungs （17/22） and cavities （11/22）. After anti?tuberculosis treatment， the absorption of lung lesions in some patients was poor， and the absorption of the lesions was improved after anti?nocardia treatment. 8 cases were cured， 13 cases were improved and 1 case died. Conclusion The clinical symptoms of patients with pulmonary tuberculosis complicated with Nocardia farcinica were atypical， the culture period of Nocardia was long， and the imaging manifestations were similar to pulmonary tuberculosis， which is prone to misdiagnosis and missed diagnosis. For patients with poor response to anti?tuberculosis treatment and slow lesion absorption， the possibility of a concurrent Nocardia infection should be considered.

Objective Investigation of the expression and clinical significance of circular RNA hsa_circ_0003922 in endometrioid carcinoma （EEC）. Methods Three EEC tissues and three normal endometrial tissues were selected for high-throughput molecular sequencing to identify specific circRNAs and related functional molecules. Additionally， 36 EEC patients were selected as the experimental group， while 36 patients with benign uterine lesions served as the control group. The differentially expressed hsa_circ_0003922 was chosen as the research target， and its expression in EEC tissues and the control group was detected using real-time fluorescence quantitative PCR （RT-qPCR）. The relationship between its expression level and clinical pathological features of EEC was analyzed. Furthermore， the miRNAs associated with hsa_circ_0003922 were predicted. The receiver operating characteristic （ROC） curve analysis was employed to evaluate the diagnostic value of hsa_circ_0003922 for EEC. Results The results of high-throughput molecular sequencing showed that there were 293 differentially expressed circRNAs in EEC tissues compared to the control group， including 115 upregulated and 178 downregulated circRNAs. RT-qPCR further revealed that the expression of hsa_circ_0003922 was significantly decreased in EEC tissues compared to the control group （P < 0.05）. The expression level of hsa_circ_0003922 was significantly negatively correlated with FIGO staging and histological grading of EEC （P < 0.05）. The area under the ROC curve （AUC） for hsa_circ_0003922 in distinguishing EEC patients from the control group was 0.7724 （P<0.05）. Conclusion The expression of hsa_circ_0003922 is associated with FIGO staging and histological grading of EEC， indicating its potential as a reference index for auxiliary diagnosis， prognosis evaluation， and as a potential molecular target for adjuvant therapy in EEC.

Objective To compare the efficacy of triangular anchor reduction forceps and towel forceps in the treatment of long oblique or spiral distal tibial fractures. Methods The data of 58 patients admitted to the Department of Traumatic Orthopaedics in Second Affiliated Hospital of Anhui Medical University from June 2019 to March 2021 were analyzed prospectively. According to the reduction methods during operation， they were divided into point reduction forceps group （n = 26） and triangle anchor reduction forceps group （n = 32）. The operation time， intraoperative fluoroscopy times， intraoperative blood loss， postoperative fracture reduction quality， hospital stay， fracture healing time， American orthopedic foot and ankle society （AOFAS） score， curative effect and complications at the last follow-up were compared between the two groups. Results All patients participated in the follow-up for more than one year. There was no significant difference in age， sex， basic diseases and injury mechanism between the two groups. The operation time and fluoroscopy times of patients in triangle anchor reduction group were significantly lower than those in point reduction forceps group （P < 0.05）， while the quality of fracture reduction was higher than that in point reduction forceps group （P < 0.05）， and there was no significant difference in other perioperative indexes. The fracture healing time of patients in triangle anchor reduction group was shorter， and the ankle joint function was better than that in point reduction forceps group （P < 0.05）. There was no significant difference in the incidence of various complications between the two groups， but the overall incidence of complications in the triangle anchor reduction group was significantly lower （P < 0.05）. Conclusion Triangular anchor reduction forceps can improve the quality of fracture reduction， shorten the healing time of fracture， reduce the occurrence of complications， reduce the operation time and the number of fluoroscopy during operation， and there is no obvious increase in local infection. It is an effective and reliable reduction method.

Objective To evaluate the improvement in the quality of early postoperative recovery in patients undergoing cardiac valve surgery with remimazolam?based fast?track anesthesia， and to provide a reference for the clinical optimization of fast?track anesthesia and Enhanced Recovery After Surgery （ERAS） protocols. Methods We selected elective surgery patients undergoing median sternotomy for cardiac valve replacement and/or repair under general anesthesia with extracorporeal circulation. Based on routine anesthesia assessment and fast?track anesthesia suitability assessment， a total of 228 patients were strictly enrolled according to the inclusion and exclusion criteria and randomly divided into two groups： the Remimazolam group （n = 114） and the Propofol group （n = 114）. Patients in the Remimazolam group were induced and maintained with remimazolam for anesthesia， while patients in the control group were administered propofol. We recorded the general information and surgical data of the patients； the QoR?15 scores before surgery （1 day preoperatively）， 1 day postoperatively， 3 days postoperatively， and 1 day before discharge； as well as hemodynamic parameters at key time points after admission， the incidence of hypotension and bradycardia after anesthesia， the duration of surgery， anesthesia duration， postoperative mechanical ventilation time， ICU stay， postoperative hospital stay， and the incidence of perioperative cardiovascular adverse events and the incidence of early postoperative complications. Results There was no statistically significant difference in general data and QoR?15 scores between the two groups 1 day before surgery （P > 0.05）. The QoR?15 score of the Remimazolam group 1 day before discharge was higher than that of the Propofol group， with a statistically significant difference （P < 0.05）， but the difference was less than the minimum clinically important difference， which is less than 8， indicating no significant clinical benefit. One minute after intubation and one minute after skin incision， the heart rate in the Propofol group slowed down and the Mean Arterial Pressure （MAP） significantly decreased， with a statistically significant difference between the groups （P < 0.05）； there was no statistically significant difference in heart rate and MAP at other times. The incidence of intraoperative hypotension and bradycardia was lower in the Remimazolam group than in the Propofol group， with a statistically significant difference （P < 0.05）. The duration of postoperative mechanical ventilation， ICU stay， postoperative hospital stay， and the rate of re?intubation were all shorter in the Remimazolam group than in the Propofol group， and the success rate of fast?track anesthesia was higher in the Remimazolam group， with a statistically significant difference （P < 0.05）. There was no statistically significant difference in the incidence of perioperative complications between the two groups. Conclusions Compared with the commonly used intravenous anesthetic propofol， the remimazolam?based fast?track anesthesia regimen did not significantly improve the postoperative recovery quality scores in patients undergoing cardiac valve surgery. However， remimazolam had advantages in maintaining hemodynamic stability， increasing the success rate of fast?track anesthesia， shortening postoperative ICU stay and hospital stay， and is a viable intravenous anesthetic option for cardiac surgery patients.

Objective to explore the risk assessment potential of oxLDL in patients with T2DM combined with PTB. Methods A prospective study was conducted， which included 60 cases of simple hyperlipidemia， 100 cases of PTB， 100 cases of T2DM， and 100 cases of T2DM combined with PTB. These patients visited the outpatient department of our center from June 2022 to June 2023. The PTB group， T2DM group， and T2DM combined with PTB group were further divided into subgroups based on normal blood lipids （40 cases） and hyperlipidemia （60 cases）， totaling 360 cases in the case group. Additionally， a control group consisting of 60 healthy individuals was included. The age range for inclusion in the study was between 35 to70 years old. Venous blood samples were collected from each group to detect HbA1c， INS， FSG， CHOL， TG， HDL， LDL， ApoA I and Apo B. OxLDL levels were measured using the ELISA method. Differences in levels between groups were compared. Multivariate logistic regression analysis was applied to assess the association between oxLDL levels and PTB as well as T2DM combined with PTB. Results There were no statistically significant differences in BMI， blood sugar， blood lipids， and insulin resistance between the T2DM hyperlipidemia subgroup and the T2DM combined with PTB hyperlipidemia subgroup. The oxLDL level in the T2DM hypertipidemia subgroup was more than double that of the control group， while the oxLDL level in the subgroup with normal blood lipids was significantly higher than that of the control group. Moreover， both the T2DM combined with PTB hyperlipidemia subgroup and simple hyperlipidemia group exhibited significantly elevated levels of oxLDL compared to the control group； however， there were no statistically significant differences when compared to the PTB hyperlipidemia subgroup. Correlation analysis revealed a significant positive linear correlation between TG and LDL with oxLDL in both the T2DM hyperlipidemia subgroup and the T2DM combined with PTB hyperlipidemia subgroup （R = 0.352， P < 0.05）. Additionally， CHOL and LDL levels in the PTB hyperlipidemia subgroup also showed a significant positive correlation with oxLDL （R = 0.441， P < 0.05）. Multivariate logistic regression analysis indicated that having oxLDL levels more than double that of the control group was an independent risk factor for both PTB and T2DM combined with PTB （P < 0.05）. Conclusion The significantly elevated levels of oxLDL may serve as a potential risk factor for the comorbidity of T2DM and PTB. It is recommended to consider oxLDL levels exceeding twice those of the control group as a clinically meaningful pathological threshold for further assessment.

Objective The evaluation of lymph node properties before lung cancer surgery has a great impact with the choice of surgical methods. Although there are various examination methods， many methods have invasive or accuracy problems. In order to improve the accuracy of diagnosis， we mainly discuss the value of wide?body spectral CT in the differential diagnosis of mediastinal metastatic lymph nodes， non?metastatic lymph nodes in lung cancer patients and reactive hyperplastic lymph nodes. Methods The clinical and imaging data of 64 patients with lung cancer and 28 patients with pulmonary inflammatory lesions were retrospectively analyzed. All patients underwent plain scan and enhanced dual?phase spectral CT scan. The size， density， three?phase IC， NIC， and λHU of lymph nodes in metastatic， non?metastatic and inflammatory reactive hyperplasia groups were measured on 70 keV single?energy images and iodine?based images， respectively. The single?factor variance and Kruskal?Wallis H rank sum test were used to analyze and compare the differences. Results The short diameter of metastatic lymph nodes was larger than that of non?metastatic lymph nodes and reactive hyperplastic lymph nodes （P < 0.001）. The plain scan density of reactive hyperplastic lymph nodes was higher than that of metastatic lymph nodes （P < 0.001）， but there was no significant difference between non?metastatic lymph nodes （P = 0.325）. The CT values of reactive hyperplastic lymph nodes in arterial phase and venous phase were higher than those of metastatic and non?metastatic lymph nodes （P < 0.05）. Except for NIC in arterial phase， IC， NIC and λHU in plain scan， IC and λHU in arterial phase， IC， NIC and λHU in venous phase of reactive hyperplastic lymph nodes and metastatic lymph nodes were statistically significant （all P < 0.05）. There was no significant difference in IC， NIC and λHU between reactive hyperplastic lymph nodes and non?metastatic lymph nodes in plain scan， arterial phase and venous phase （all P > 0.05）. Conclusion The quantitative and spectral curve slope of iodine in mediastinal metastatic lymph nodes of lung cancer were basically lower than those in reactive hyperplastic lymph nodes. The quantitative parameters of spectral CT had certain diagnostic efficacy in differentiating metastatic lymph nodes and reactive hyperplastic lymph nodes， while the spectral parameters of non?metastatic lymph nodes and reactive hyperplastic lymph nodes were not statistically significant.

Objective To investigate the correlation between exposure of uric acid accumulation and the risks of acute pancreatitis （AP） in the population in Kailuan Group. Methods A prospective study was performed based on thesubjects receiving annual physical examination during 2006 to 2010 in Kailuan Group. All of them had no AP history but had complete data on UA. The starting point of follow-up was when the subjects completed the health examination in 2010， and the end point was new AP events， deaths or the end of follow-up （2021-12-31）. Exposure of uric acid accumulation （cumUA） was calculated according to the average values of uric acid measured in each two consecutive physical examinations and the intervalbetween these two consecutive physical examinations. The cumulative incidences of AP indifferent subgroups （determined by the quartile of cumUA） were described using Kaplan-Meier product limit-method and compared by log-rank test. Multivariate Cox proportional hazards regression model was used to analyze the impacts of different cumUA subgroups on new occurrence of AP events. Results A total of 55，799 subjects were included in this study. The subjects were divided into four groups according to the quartile of cumUA. Sex ratio， average age， BMI， systolic blood pressure （SBP）， diastolic blood pressure （DBP）， FPG， TC， TG， LDL-C， HDL-C， smoking， alcohol consumption， education ≥ 9 years， physical exercise， history of hypertension， and history of cholelithiasis differed significantly among the groups （P < 0.05）， there was no difference in diabetes history among the 4 groups （P = 0.30）. 153 patients developed AP during an average follow-up of （10.52 ± 1.75） years， the incidence rates were 1.65， 2.76， 2.13 and 3.96 per 10 000 person-year in the Q1， Q2， Q3and Q4， respectively （P < 0.01）. After adjusting sex， age， TC， TG， eGFR， smoking， alcohol consumption， education， physical activity， and history of hypertension， diabetes， or cholelithiasis， Multivariate analysis showed a significantly increased risk in Q4 （HR = 1.77， 95%CI： 1.07 ~ 2.92） as comparing with Q1. After excluding deaths during the follow-up period， Multivariate Cox regression analysis was performed again in Q4 HR = 1.75 （95%CI： 1.04 ~ 2.95）. Conclusions With the increase of cumUA exposure， both morbidity and risk of AP occurrence have the tendency of rising.

Objective To investigate the status quo and influencing factors of knowledge， attitude and practice （KAP） of hyperuricemia health management in community medical staff， and to put forward improvement strategies for enhancing the community health management of hyperuricemia. Methods A mixed methodology of both qualitative and quantitative research was employed in the study. In August 2022， the convenience sampling method was adopted to conduct a questionnaire survey on the knowledge and practice of hyperuricemia health intervention among 193 medical staff in Guangzhou community health service centers， to understand the knowledge and health management behavior of primary medical staff on hyperuricemia health management. Objective sampling method was used to conduct semi?structured interviews with 14 community medical workers to understand the status quo of community health management of hyperuricemia. Results The results of quantitative study showed that the knowledge and practice scores of community medical staff on health management of hyperuricemia were （73.60 ± 10.06）. There was a significant positive correlation between knowledge， attitude and practice of hyperuricemia management （P < 0.01）. Age， education background， occupation and participation in hyperuricemia management training were the influencing factors of health management knowledge， attitude and practice scores （P < 0.05）. The qualitative study found that the community focused on treatment rather than prevention of hyperuricemia health management， lacked effective incentive mechanism and did not realize quality division of labor cooperation within the team， and residents were not very active in participating in hyperuricemia health management activities. Conclusion The knowledge of hyperuricemia management of community health care workers was at a medium level， and the attitude towards hyperuricemia health intervention was positive， but the behavioral score was not ideal， the breadth and depth of community hyperuricemia health management services were insufficient， and the cooperation of residents was low. In the future， it is necessary to strengthen the training and practical guidance for community health care workers in hyperuricemia health management， optimize the functional deployment of community health management teams， enrich the connotation of health management services， and improve the level of community hyperuricemia health management.

Objective To explore the clinical effect of umbilical moxibustion on chronic heart failure with yang deficiency and blood stasis and water retention syndrome. Methods 80 patients with chronic heart failure who were hospitalized in the Department of Cardiology， Shenzhen Hospital （Longgang）， Beijing University of Chinese Medicine from January 1， 2021 to December 31， 2022 were selected as research samples and randomly divided into control group （40 cases， 40 cases completed） and observation group （40 cases， 40 cases completed）. The control group received standard drug treatment， while the observation group received umbilical moxibustion treatment on the basis of drug treatment. Ten days after treatment， NT-proBNP， NYHA cardiac function classification， cardiac color Doppler indexes （including LVEF， LVEDD， LVSD）， Minnesota quality of life score， 6-minute walking distance and TCM syndrome score were compared between the two groups before and after treatment， and the occurrence of adverse reactions was monitored and recorded. Results The total effective rate in the observation group was higher than that in the control group （χ² = 3.865， P = 0.049）. NYHA cardiac function classification， NT-proBNP， LVEF， LVEDD， LVESD and 6-minute walking distance in both groups were significantly improved compared with those before treatment， and the improvement of the above indexes in the observation group was more significant （P < 0.05）. The Minnesota quality of life score and TCM syndrome score of the two groups decreased compared with those before treatment， and the decline of the patients in the observation group exceeded that of the control group （P < 0.05）. During the treatment， the two groups had adverse reactions （such as gastrointestinal reaction， hypotension， skin allergy， etc.）， and there was no difference between the two groups （P > 0.05）. Conclusion On the basis of drug therapy， umbilical moxibustion is better than simple drug therapy in treating chronic heart failure with yang deficiency， blood stasis and water stagnation， which can improve the cardiac function and quality of life of patients with chronic heart failure.

Glioma is the most common primary tumor of the brain， accounting for 81 % of central nervous system （CNS） malignant tumors. The degree of malignancy is high， and the current treatment methods are limited. In recent years， with the in-depth study of intestinal flora and brain-gut axis， it has been found that the diversity of gut microbiota plays an important role in the regulation of glioma. The mechanism is that the intestinal flora affects the development of glioma through the role of immune regulation and metabolites. In addition， it has been confirmed that there is a certain correlation between some probiotics and glioma， which provides a new application prospect for the treatment of glioma. This paper discusses the main intestinal bacteria that regulate gliomas as well as the role and regulatory mechanisms of intestinal flora in the development of gliomas， and provides ideas for the discovery of new targets for glioma treatment and further improvement of treatment options.

Acute-on-chronic liver failure （ACLF） is a group of clinical syndromes related to severe acute liver function damage and multiple organ failure caused by various acute inducing factors on the basis of chronic liver disease. Due to its serious condition， rapid progression and high mortality， it has attracted more and more attention. Recent studies have shown that the pathogenesis of ACLF mainly includes direct injury and immune injury. As the main immune cells in the liver， the immunoregulatory role of liver macrophages in ACLF has been increasingly recognized. Liver macrophages have excellent phenotype conversion function and plasticity characteristics under the influence of epigenetic reprogramming or local microenvironment. This adaptive expression ability can use key mediators to promote the early conversion of anti-inflammatory phenotype to alleviate liver injury. A large number of studies have shown that liver macrophages have a certain potential in reversing the process of ACLF. Therefore， from the perspective of the plasticity characteristics of liver macrophages， this paper expounds the role of liver macrophages in ACLF and the research on the intervention of ACLF disease process， and summarizes its potential significance in the treatment of ACLF.

Statins， known as hydroxymethylglutaryl coenzyme A reductase （HMG?CoA） inhibitors， are primarily used to lower blood lipids， preventing and treating cardiovascular diseases. Research indicates that statins exhibit multiple effects in the prevention and treatment of colorectal cancer. They function by inhibiting the MVA pathway， suppressing inflammation， enhancing cellular immunity， and influencing the gut microbiota， positively impacting the onset and progression of colorectal cancer. Clinical studies have additionally uncovered that statin drugs can augment the effectiveness of chemotherapy， immunotherapy， and adjuvant therapies， acting as both preventive and adjunctive measures for colorectal cancer. This article critically reviews the research progress on statins in colorectal cancer， aiming to establish a theoretical foundation for exploring innovative treatment options.