Abstract:

Objective To investigate the effect of mechanical thrombectomy using Solitaire stent combined with dual antiplatelet therapy （DAPT） on limb function and vascular reocclusion in patients with acute cerebral infarction. Methods A total of 134 patients with acute cerebral infarction who received treatment in our hospital from February 2020 to August 2023 were selected as samples. According to whether the patients regularly took aspirin and clopidogrel every day one week before surgery， they were divided into observation group（taking the medications）and control group （without taking medications）， with 67 cases in each. The control group was given mechanical thrombectomy， and the observation group was treated with DAPT combined with mechanical thrombectomy. Outcomes measured included revascularization one week after treatment， and neurological and limb function assessment using NIHSS and FMA scale at baseline， 1 day， 1 week， and 1 month after treatment. Brain hemodynamics （CVR， Qmean， and Vmean） and thrombosis markers （TXB2， CD62P， and 6-keto-PGF1α） were evaluated pre-treatment and one month after treatment. Vascular reocclusion three months after treatment and its correlation with hemodynamics and thrombosis factors were analyzed. Results After treatment， higher revascularization rate， FMA score， Qmean， Vmean， and 6-keto-PGF1α level， and lower NIHSS score， CVR， TXB2， and CD62P level were found in the observation group （P < 0.05）. The incidence of vascular reocclusion was also lower in the observation group. Logistic analysis indicated that brain hemodynamic indicators and the level of thrombosis-related factors influenced vascular reocclusion occurrence （P < 0.05）. Conclusion Mechanical thrombectomy using Solitaire stent combined with DAPT helps the recovery of limb function in patients with acute cerebral infarction and reduces the risk of vascular reocclusion.

Key words: mechanical thrombectomy using Solitaire stent, dual antiplatelet therapy, acute cerebral infarction, limb function, vascular reocclusion