肝巨噬细胞及其可塑性特征对治疗慢加急性肝衰竭的潜在价值及研究进展

doi:10.3969/j.issn.1006-5725.2024.14.023

Abstract

Abstract:

Acute-on-chronic liver failure （ACLF） is a group of clinical syndromes related to severe acute liver function damage and multiple organ failure caused by various acute inducing factors on the basis of chronic liver disease. Due to its serious condition， rapid progression and high mortality， it has attracted more and more attention. Recent studies have shown that the pathogenesis of ACLF mainly includes direct injury and immune injury. As the main immune cells in the liver， the immunoregulatory role of liver macrophages in ACLF has been increasingly recognized. Liver macrophages have excellent phenotype conversion function and plasticity characteristics under the influence of epigenetic reprogramming or local microenvironment. This adaptive expression ability can use key mediators to promote the early conversion of anti-inflammatory phenotype to alleviate liver injury. A large number of studies have shown that liver macrophages have a certain potential in reversing the process of ACLF. Therefore， from the perspective of the plasticity characteristics of liver macrophages， this paper expounds the role of liver macrophages in ACLF and the research on the intervention of ACLF disease process， and summarizes its potential significance in the treatment of ACLF.

Key words: acute-on-chronic liver failure, macrophage, cell plasticity, immunomodulation

CLC Number:

R575.3

Guirong CHEN,Minggang WANG,Huaming LIN,Xinxin CHEN,Juan LUO,Fengqin YE,Xiufeng. WANG. Potential value of liver macrophages and their plasticity in the treatment of ACLF[J]. The Journal of Practical Medicine, 2024, 40(14): 2035-2040.

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Potential value of liver macrophages and their plasticity in the treatment of ACLF

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