Abstract:

Objective To investigate the effects of different doses of dexmedetomidine on the loss of con⁃ sciousness ED95 caused by remimazolam and the stress response to tracheal intubation during induction of general anesthesia. Methods Eighty ⁃ seven patients under general anesthesia with tracheal intubation were selected and randomly assigned to the remimazolam group（group R），0.5 μg/kg dexmedetomidine combined with remimazolam group（group RD1）and 1.0 μg/kg dexmedetomidine combined with remimazolam group（group RD2）. The three groups were infused with saline，dexmedetomidine 0.5 μg/kg and 1.0 μg/kg，respectively，followed by the sequen⁃ tial pumping of remimazolam. The ED95 and 95% CI for loss of consciousness due to remimazolam were calculated. Results The ED95 and 95% CI for remimazolam were 0.250（0.234 ~ 0.397），0.199（0.190 ~ 0.258），and 0.184 （0.172 ~ 0.282）mg/kg in three groups respectively. Conclusion Preinfusion of dexmedetomidine 0.5 μg/kg and 1.0 μg/kg both reduced the ED95 of rimazolam⁃induced loss of consciousness in patients and attenuated intubation stress. However，application of dexmedetomidine 1.0 μg/kg had the risk of causing heart rate slowing.

Key words:

remimazolam, dexmedetomidine, dose?respondse relationship, stress