Abstract:

Objective There is no research on the relationship between neutrophil to lymphocyte ratio （NLR）and red blood cell distribution width（RDW）and brain damage caused by febrile convulsions in children. Therefore，this study was aimed to explore the expression of NLR and RDW in febrile convulsions in children，and to analyze its relationship with brain damage. Methods A total of 212 children with febrile seizurestreated in our hospital from April 2017 to August 2019 wereselectedand divide into simple group（n = 126，simple febrile seizures） and complex group（n = 86，complex febrile seizures）according to their clinical manifestations，another 86 children with fever but no convulsions received in the outpatient department of our hospital were selected as the fever but with no convulsions group. The blood routine test index levels of the 3 groups were compared ，the differential diagnosis value of NLR，RDW for simple and complex febrile seizures were analyzed using ROC curve；a total of 212 cases of febrile seizures were divided into brain injury group（n = 30）and no brain injury group（n = 182） according to whether the children complicatedbrain injury，the relationship between NLR，RDW and brain injury caused by febrile convulsion in children were analyzed using ROC curve. Results The levels of WBC，RBC， NLR and RDW in the simple group and the complex group were higher than those in the fever butwith no convul⁃ sions group，and the levels of NLR and RDW in the complex group were higher than those in the simple group（all P < 0.05）. ROC curve analysis results showed that the diagnostic sensitivity and specificity of NLR for simple and complex febrile convulsions were 70.05% and 65.55%，area under the curve（AUC）was 0.766；RDW was 68.77%， 60.04% and 0.748，respectively. Logistic regression analysis showed peripheral blood levels of NLR and RDW were positively correlated with brain injury in children with febrile seizures （P < 0.05）；ROC curve analysis showed that the sensitivity and specificity of NLR for the diagnosis of brain injury in children with febrile seizures were 75.40% and 70.06%，AUC was 0.848；RDW was 77.70%，68.88% and 0.870，respectively. Conclusions The levels of NLR and RDW in the peripheral blood of children with febrile seizures are abnormally increased，and the levels of NLR and RDW in the peripheral blood of children with complex febrile seizures are significantly higher than those of simple febrile seizures，and thelevels of NLR and RDW increase when accompanied with brain injury more obviously，the level of peripheral blood NLR and RDW could be used to differentially diagnose the types of febrile convulsions in children and predict whether it is accompanied by brain injury. 

Key words:

neutrophil to lymphocyte ratio, red blood cell distribution width, febrile convulsions, brain injury, diagnostic value