Abstract:

Objective To investigate the clinical value of combined detection of alpha⁃fetoprotein（AFP）， alpha⁃fetoprotein alloplasm⁃3 ratio（AFP⁃L3%）and Golgi somal glycoprotein 73（GP73）in primary liver cancer. Methods The levels and positive rates of AFP，AFP⁃L3% and GP73 in serum of patients with chronic hepatitis， liver cirrhosis and primary liver cancer were detected，and the data were compared. Results AFP levels in chronic hepatitis group，cirrhosis group and primary liver cancer group were（97.1 ± 88.2）ng/mL，（208.2 ± 204.1）ng/mL， （284.5 ± 275.2）ng/mL respectively，which were significantly higher than those in the control group. AFP positive rate in primary liver cancer group was 53.3%，which was significantly different from the other three groups. The level of AFP ⁃ L3% and the positive rate of AFP ⁃ L3% in primary liver cancer group were（32.8±21.3）% and 75.0%，respectively，the level of which were significantly higher than the other three groups. The levels of GP73 in chronic hepatitis，cirrhosis and primary liver cancer groups were significantly higher than those in the control group. The levels of GP73 in cirrhosis and primary liver cancer groups were 234.3 ± 91.8 ng/mL and 224.3 ± 83.7 ng/mL，respectively. There was no significant difference between the two groups. The positive rate of GP73 was the highest in the cirrhosis group（71.9%）. The sensitivity and specificity of the combined detection of the three indexes were 91.10% and 97.2%，respectively，and the AUC was 0.942，which was higher than that of the single detection index. Conclusion AFP⁃L3% and GP73 should be monitored at the same time when AFP is used as an auxiliary diagnostic index of primary liver cancer. GP73 is of high value in the diagnosis of liver cirrhosis and primary liver cancer. If the three tests are carried out at the same time，the sensitivity rate and accuracy of chronic hepatitis， cirrhosis and primary liver cancer can be improved. Thus，the value of early diagnosis of primary liver cancer can be improved，in the prediction of early primary liver cancer has important significance.

Key words:

Alpha fetoprotein, Alpha?fetoprotein heteroplasms, Golgi body transmembrane glycopro? tein 73, primary liver cancer, diagnostic value