Abstract:

Objective To investigate the physical and neurological prognosis of extremely preterm infants （EPIs）at corrected age of 6 months in order to provide basis for parents and doctors to make treatment decisions. Methods Retrospectively，the follow⁃up data of EPIs who survived and discharged from our hospital from 2015 to 2019 within corrected age of 6 months were analyzed. Results （1）Totally，63 EPIs survived and discharged in our hospital，11 out of follow⁃ups after discharge，and then 52 included in this study. The gestational age at birth was 26.18 to 27.55 weeks，and the birth weight 840 to 1040 g.（2）The incidence of extrauterine growth retardation （EUGR）in weight was 75.00%，38.46%，23.07% the incidence of EUGR in head circumference was 78.84%， 23.08%，25.64%，and the incidence of EUGR in body length was 76.92%，40.38%，12.82% at discharge，the corrected gestational age of 40 weeks and corrected age of 6 months，respectively.（3）By Infant Neurological Inter⁃ national Battery（Infanib），transition 51.28% of them were scored between 49 ~ 65，a medium level and 48.72% higher than 66，a normal level，at the corrected age of 3 ~ 6 months.（4）By Gesell Development Scale the propor⁃ tion of mild to moderate abnormal development quotient（DQ）of gross motor movement，fine movement，adaptabil⁃ ity，language and personal social contact at the corrected age of 3 ~ 6 months were 32.43%，10.81%，32.43%， 10.81%，13.51%，respectively；Among them，21（56.75%）were scored > 75 in the five functional areas.（5）By Bayley Development Scale at the corrected age of 6 months，1 case（2.70%）was scored < 70 for MDI，3 cases （8.11%） < 70 in PDI，1 case（2.70%）< 70 in MDI and PDI，and 19 cases（51.35%）≥ 80 in both MDI and PDI. MDI or PDI with the score <80 was associated with long hospital stay and necrotizing enterocolitis（NEC）.（6）blindness or deafness was found. Conclusion At the corrected age of 6 months，40% ~ 50% of the premature in⁃ fants are in a mild abnormal state neurologically. Further standardized follow⁃up and early neurological intervention are needed for these children in order to reduce the occurrence of adverse neurological prognosis. 

Key words:

neurodevelopment, physical development, developmental quotient, extremely preterm infants, prognosis