Abstract:

Objective To investigate the clinical value of vascular endothelial growth factor（VEGF）and angiopoietins 2（Ang ⁃ 2）in diagnosis of papillary thyroid carcinoma（PTC）and its concomitant cervical lymph node metastasis. Methods A total of 86 PTC patients confirmed by pathology（41 PTC patients without cervical lymph node metastasis and 45 PTC patients with cervical lymph node metastasis）were selected. The expression levels of VEGF and Ang⁃2 in PCT tissues and adjacent normal thyroid tissues were detected by MaxVisionTM method of immunohistochemical staining，and the above related clinical data were recorded. Results （1）The expression level of VEGF in PTC tissues was significantly higher than that in adjacent tissues（P < 0.05）. There was no differ⁃ ence in the expression level between PTC without cervical lymph node metastasis and PTC with cervical lymph node metastasis（P > 0.05）.（2）The expression of Ang⁃2 in PTC tissues was significantly higher than that in para⁃ carcinoma tissues（P < 0.05）. There was no difference in expression levels between PTC tissues without cervical lymph node metastasis and those with cervical lymph node metastasis（P > 0.05）. Conclusion VEGF and Ang⁃2 have certain clinical significance in assisting diagnosis of PTC. VEGF and ANG⁃2 may have no diagnostic value in predicting whether PTC associating with cervical lymph node metastasis. 

Key words:

papillary thyroid carcinoma, vascular endothelial growth factor, angiopoietins?2, lymph node metastasis