肿瘤细胞迁移关键调节因子Rho GTPase激活蛋白研究进展

doi:10.3969/j.issn.1006-5725.2025.11.021

Abstract

Abstract:

Rho GTPase-activating proteins （ARHGAP） constitute a family of multifunctional regulatory proteins that negatively regulate Rho family GTPases （e.g.， RhoA， Rac1， Cdc42） by accelerating the hydrolysis bound to these enzymes. Members of this family are extensively involved in crucial biological processes such as cellular signal transduction， adhesion， and dynamic reorganization of cytoskeleton， while also playing significant roles in tumor progression. ARHGAP expression and function vary across cancer types， with identical molecule exhibiting divergent expression levels and biological effects in various malignancies. The regulatory effects of ARHGAP family members on tumor cell migration are closely associated with their unique structural domain characteristics and are modulated by multiple signaling pathways. This paper comprehensively analyzes and summarizes existing research to explore the roles and mechanisms of ARHGAP family members in tumor cell migration， aiming to identify potential biomarkers and therapeutic targets in cancer management and prevention.

Key words: ARHGAP, Rho GTPase, tumor, migration, signaling pathway

CLC Number:

R730

Shihan CHEN,Yong JI,Wei ZHU. Research progress of Rho GTPase activating protein for regulator of tumor cell migration[J]. The Journal of Practical Medicine, 2025, 41(11): 1751-1759.

Figures/Tables 2

Fig.1

Tab.1

The ARHGAP - related migration mechanisms of various tumor cells in cancers"

肿瘤类型	基因名称	迁移机制	参考文献
乳腺癌	ARHGAP1	TGF-β信号通路；	［59］
	ARHGAP5	METTL3介导m6A修饰	［60］
	ARHGAP19	miR-194调控靶基因	［61］
	ARHGAP25	Wnt/β-catenin信号通路	［1］
前列腺癌	ARHGAP1	hsa-miR-940促进hMSCs的成骨分化	［4］
	ARHGAP5	hsa_circ_0003258通过miR-653-5p调控靶基因	［62］
肺癌	ARHGAP6	VEGF的调控STAT3信号通路	［63］
	ARHGAP9	Wnt/β-连环蛋白信号通路	［64］
	ARHGAP10	PI3K/AKT/GSK3β信号通路	［65］
	ARHGAP25	HOXA4调控靶基因和Wnt/β-catenin信号通路	［41］
结直肠癌	ARHGAP4	TGF-β信号通路	［66］
	ARHGAP5	miR-137调控靶基因	［67］
	ARHGAP8	Rho和Rac信号通路	［37］
	ARHGAP15	PTEN/AKT/FOXO1信号通路	［68］
	ARHGAP25	Wnt/β-连环蛋白信号通路	［69］
	ARHGAP35	E3泛素连接酶TRIM65介导泛素化	［70］
宫颈癌	ARHGAP1	MMP2、ZEB1、CCNB1、Twist、PCNA的调控	［13］
	ARHGAP5	乳酸刺激miR-744调节靶基因	［71］
	ARHGAP30	F-肌动蛋白/Hippo-YAP信号	［72］
胰腺癌	ARHGAP4	miR-939-5p调控靶基因	［73］
	ARHGAP30	β-catenin信号通路	［74］
卵巢癌	ARHGAP5	lncRNA ZFHX2-AS1与DKC1相互作用靶基因	［75］
	ARHGAP10	Cdc42活性调控	［39］
	ARHGAP26	SMURF 1调控靶基因和β-catenin信号通路	［76］
	ARHGAP30	PI3K/AKT/mTOR信号通路	［77］
胃癌	ARHGAP5	SIRT1与c-JUN的相互作用调节靶基因	［78］
	ARHGAP11A	miR-30c-2-3p调控靶基因	［45］
	ARHGAP18	MAPK信号通路	［79］
膀胱癌	ARHGAP5	CircUBE2K通过miR-516b-5p调控靶基因	［80］
	ARHGAP6	β-catenin信号通路	［63］
鼻咽癌	ARHGAP12	细胞骨架重塑相关蛋白的调控	［81］
	ARHGAP42	PI3K/AKT信号通路	［82］
肝癌	ARHGAP7	HBc参与miR-382-5p调控靶基因	［83］
	ARHGAP20	PI3K/AKT信号通路	［9］
	ARHGAP24	β-catenin信号通路	［84］
骨肉瘤	ARHGAP24	circ-LOM7靶向miR-21-5p调控的靶基因	［85］
黑色素瘤	ARHGAP29	EHMT2通过靶基因调节RhoA通路	［86］

Tab.1

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Research progress of Rho GTPase activating protein for regulator of tumor cell migration

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