黏蛋白MUC5AC在肺炎支原体肺炎患儿气道中的表达及临床意义

doi:10.3969/j.issn.1006-5725.2023.20.011

Abstract

Abstract:

Objective To investigate the expression of mucin 5AC （MUC5AC） in airway of children with mycoplasma pneumoniae pneumonia（MPP）， and to provide clinical value for early diagnosis and treatment of MPP mucus plug. Methods A total of 94 children with MPP who were hospitalized for alveolar lavage from April 2022 to October 2022 were included in the MPP group. According to whether mucus plug was observed under the first fiberoptic bronchoscope， the MPP group was divided into mucus plug group （n = 41） and non-mucus plug group （n = 53）. Relevant clinical data and laboratory examination data were collected. Results Compared with non mucus plug group， the mucus plug group had a longer heat duration and hospital stay， and the levels of CRP， LDH，PCT， D-dimer， MP-DNA copy value of lavage fluid， IL-17， MUC5AC were all increased，with statistically significant differences （P < 0.05）. MUC5AC was positively correlated with LDH and IL-17 levels （r = 0.54， P = 0.002； r = 0.39， P = 0.019）. The ROC curve plotted based on the level of MUC5AC had an area under the ROC curve of 0.811， a sensitivity of 86.2% and a specificity of 71.4% for predicting formation of mucus plug in MPP. Conclusions There was an increase in the level of MUC5AC in children with mucus plug group in MPP， and the level of MUC5AC had a certain value for predicting mucus plug formation.

Key words: child, mycoplasma pneumoniae pneumonia, MUC5AC

CLC Number:

R563.1

Li PENG,Lili ZHONG,Lin LIN,Han HUANG,Xiaofang DING,Min CHEN,Xiaojuan. LIN. Expression and clinical significance of MUC5AC in airway of children with mycoplasma pneumoniae pneumonia[J]. The Journal of Practical Medicine, 2023, 39(20): 2618-2622.

Figures/Tables 3

Tab.1

Fig.1

Fig.2

References 24

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项目	黏液栓组（n = 41）	非黏液栓组（n = 53）	χ ² /t/Z值	P值
性别（例）			1.492	0.298
男	18	30
女	23	23
发病年龄（岁）	6.26 ± 1.80	5.21 ± 2.01	2.538	0.013
氧饱和度异常（< 0.95）［例（%）］	6（14.63）	1（1.89）	5.450	0.020
入院时病程［M（P₂₅，P₂₅），d］	8（7，12）	7（6，10）	-0.389	0.698
热程［M（P₂₅，P₂₅），d］	8.60 ± 3.57	4.00 ± 1.46	2.39	0.026
住院时间（d）	9.73 ± 3.47	6.93 ± 2.81	2.42	0.022
WBC（× 10⁹/L）	9.57 ± 3.18	9.15 ± 2.40	0.402	0.691
PLT（× 10⁹/L）	342 ± 160	359 ± 105	-0.338	0.738
CRP［M（P₂₅，P₂₅），mg/L］	13（2，27）	8（1，14）	-2.615	0.009
PCT［M（P₂₅，P₂₅），μg/L］	0.15（0.12，0.34）	0.08（0.04，0.15）	-2.266	0.023
LDH（U/L）	391.36 ± 140.02	325.02 ± 92.39	2.625	0.01
ALT（U/L）	25.82 ± 11.28	17.38 ± 8.11	1.184	0.251
D二聚体［M（P₂₅，P₂₅），mg/L］	0.93（0.57，1.61）	0.54（0.30，1.10）	-2.05	0.04
IgA（g/L）	1.42 ± 0.85	1.33 ± 0.62	0.317	0.754
IgG（g/L）	9.95 ± 0.55	9.46 ± 0.74	-0.538	0.595
IgM（g/L）	2.27 ± 1.11	1.35 ± 0.43	1.089	0.294
肺实变［例（%）］	37（90.24）	13（24.53）	40.096	< 0.001
胸腔积液［例（%）］	19（46.34）	3（5.66）	21.341	< 0.001
重症MPP［例（%）］	28（68.29）	14（26.42）	16.402	< 0.001
灌洗液log10 MP-DNA	7.14 ± 2.71	6.35 ± 1.17	3.119	0.003
MUC5AC（ng/mL）	7.58 ± 2.31	5.36 ± 1.41	2.732	0.014
IL-17（ng/mL）	47 ± 18.21	42 ± 13.12	2.391	0.029

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Expression and clinical significance of MUC5AC in airway of children with mycoplasma pneumoniae pneumonia

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