Abstract:

Objective To investigate the clinical outcomes of cytoreductive radical prostatectomy（CRP） combined with androgen deprivation therapy（ADT）for oligometastatic prostate cancer. Methods A total of 67 patients with oligometastatic prostate cancer were enrolled in the study from June 2015 and March 2021. Of the patients，32 were treated with CRP combined with ADT and 35 were treated with ADT alone. The perioperative outcomes were evaluated，the time to CRPC and cancer specific survival（CSS）were observed and compared by Kaplan⁃Meier method. Results No statistical differences in PSA levels，distribution of clinical tumor stage and nodal stage were noted between the two groups. The incidence of postoperative complications in CRP group was 34.38%. Two patients experienced Clavien⁃Dindo I complications，while nine patients experienced Clavien⁃Dindo Ⅱ complications. Tewnty patients progressed to CRPC in the CRP group and 21 in the ADT group. The median time to CRPC was significantly longer among the CRP group（26 months）compared with the ADT group（19 months）. Multivariate analysis identified CRP as a significant predictor for delaying the progression to CRPC. There was no difference in CSS between the two groups. Conclusions CRP combined with ADT was effective in oligometastatic prostate cancer by delaying the progression to CRPC with few minor complications.

Key words:

oligometastatic prostate cancer, cytoreductive radical prostatectomy, androgen depriva? tion therapy, prognosis, influence factor