Abstract:

Objective To investigate the relationship between IL⁃33 expression level and clinic⁃pathological features and prognosis in patients with cervical cancer. Methods A total of 184 patients with cervical cancer in the Department of Gynecology and Obstetrics of our hospital from January 2016 to December 2017 were enrolled. The IL⁃33 expression in cervical cancer and adjacent tissues were detected by immunohistochemistry. The relationship between IL⁃33 expression and clinic⁃pathological characteristics in patients with cervical cancer was analyzed. The factors influencing the prognosis was analyzed by Cox proportional hazards analysis. Results The IL⁃33 expression was negative or weak in cervical adjacent tissues. There were 126 and 58 cases with high and low expression of IL⁃33 in cervical cancer tissues，respectively. IL⁃33 is mainly expressed in the cytoplasm of cells，showing brownish yellow and tan granules. The IL⁃33 expression level in cervical cancer tissues were significantly associated with the cell differentiation degree，depth of muscular invasion，FIGO stage and lymph node metastasis（P < 0.05）. By the end of follow⁃up，141 cases of cervical cancer patients had recurrence or death，while 43 cases had no recurrence or death. Among them，103 cases had higher IL⁃33 expression and 38 cases had lower IL⁃33 expression in patients with recurrence or death. Another 23 cases had higher IL⁃33 expression and 20 cases had lower IL⁃33 expression in patients without recurrence or death. The expression level of IL⁃33 in cervical cancer tissues between patients with poor and good prognosis was significantly different（P = 0.016）. The muscular invasion depth，FIGO stage，lymph node metastasis and higher IL ⁃ 33 expression were risk factors for poor prognosis in patients with cervical cancer （P < 0.000）. Conclusions The expression level of IL⁃33 in cervical cancer tissues was higher，which is closely related to poor prognosis. 

Key words:

cervical cancer, IL?33, clinic?pathological features, prognosis, marker