基于肠-脑轴探讨肠道菌群干预小胶质细胞在艾滋病相关神经认知障碍中的机制研究与干预策略

doi:10.3969/j.issn.1006-5725.2026.17.005

Abstract

Abstract:

HIV-associated neurocognitive disorder （HAND） is a prevalent chronic neurological complication among people living with human immunodeficiency virus （HIV）， clinically characterized by cognitive impairment that significantly reduces patients' quality of life and compromises antiretroviral treatment adherence. In recent decades， accumulating evidence has confirmed that microglia are core mediators of neuroinflammation and neuronal injury in the pathogenesis of HAND. Concurrently， research on the regulatory role of gut microbiota in central nervous system homeostasis via the gut-brain axis has attracted growing scholarly attention. This systematic review elaborates on the mechanisms by which gut microbiota modulate the metabolism and functional polarization of microglia by mediating gut-brain crosstalk， thereby influencing the onset and progression of HAND. It also summarizes existing HAND intervention strategies from the gut-brain axis perspective， aiming to provide novel insights for the mechanistic investigation and clinical prevention and treatment of HAND.

Key words: gut microbiota, microglial cells, HIV-associated neurocognitive disorder, neuroinflammation

CLC Number:

Xuanying Li, Danni Wang, Guangzong Jia, Chenglin Peng, Yunmengtong Su, Huijun Guo, Zhen Liu. Mechanistic research and intervention strategies on gut microbiota modulating microglia via the gut-brain axis in hiv-associated neurocognitive disorders[J]. The Journal of Practical Medicine, 2026, 42(17): 3074-3082.

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Mechanistic research and intervention strategies on gut microbiota modulating microglia via the gut-brain axis in hiv-associated neurocognitive disorders

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