组学技术在甲状腺功能障碍中的研究进展

doi:10.3969/j.issn.1006-5725.2025.20.020

Abstract

Abstract:

Thyroid dysfunction （TD） is a prevalent disorder of the endocrine system. Owing to its non-specific clinical symptoms and the limitations inherent in current diagnostic approaches， there is a pressing need to further investigate its underlying pathogenesis and identify novel biomarkers. As a pivotal component of systems biology， omics technologies offer a promising avenue for uncovering the molecular mechanisms of TD by integrating high-throughput data. This thesis presents a comprehensive review of recent advancements in genomics， transcriptomics， proteomics， metabolomics， lipidomics， and multi-omics research related to TD. It examines genetic variations and epigenetic regulatory mechanisms from multiple molecular levels， including DNA， RNA， proteins， and metabolites. Furthermore， it elucidates the metabolic disturbances associated with TD and the modes of action of relevant therapeutic agents， contributing to the development of potential biomarkers and drug targets for early detection and intervention. By synthesizing findings across various omics platforms， this thesis aims to delineate the complex network interactions underlying TD and to provide valuable insights and strategies for future clinical management， as well as personalized diagnosis and treatment.

Key words: thyroid dysfunction, genomics, transcriptomic, proteomics, metabolomics, lipidomics

CLC Number:

R581.9

Wenyan ZHANG,Feifei SHAO,Limin. TIAN. Research progress of omics technologies in thyroid dysfunction[J]. The Journal of Practical Medicine, 2025, 41(20): 3288-3296.

Figures/Tables 1

References 56

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组学技术	药物	样本	靶点	通路	参考文献
转录组学	玄参提取物	大鼠肝脏	LPAR3、IHH、CNTFR	Rap1、Hedgehog、Jak-STAT和PI3K-Akt信号通路	[16]
蛋白组学	卡比马唑	人尿样	SERPIN B3、血浆激肽释放酶、S100-A9蛋白、α-1B-糖蛋白、转甲状腺素蛋白	APP 、 AKT 信号通路	[24]
蛋白组学	玄参	大鼠肝脏	Aldh1a1、Aldh5a1、Cyp2c7、Hba2、Hba-a2、Ugt2a3、 ENSR-NOG00000048955	ErbB信号通路	[25]
代谢组学与网络药理学	海藻玉壶汤	大鼠血浆	PTPN11、PIK3CD、EGFR、HRAS、PIK3CA、AKT1、 SRC、PIK3CB和PIK3R1	HIF-1信号通路、EGFR酪氨酸激酶抑制剂抗性、脂质和动脉粥样硬化、内分泌抗性、甲状腺激素信号通路、糖尿病并发症中的AGE-RAGE信号通路等	[51]
代谢组学与网络药理学	玄参	大鼠粪便	PTEN、EP300和CCNB1	HIF-1信号通路、甲状腺激素信号通路、催乳素信号通路、cGMP-PKG信号通路和 cAMP 信号通路	[52]
转录组学与网络药理学	乙醇紫锥菊	小鼠肝脏	EHHADH、ACOT2、 ACO-T8、SLC27A2、 EPHX2、ACACA和HMGCR	AMPK和PPAR信号通路	[53]
蛋白质组学与转录组学	来自玄参的环烯醚萜类药物	大鼠肝脏	Spp1、Thbs1、PI3K、 Akt	PI3K-Akt信号通路	[54]

Research progress of omics technologies in thyroid dysfunction

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