脂质组学在肾脏疾病中的应用与进展

doi:10.3969/j.issn.1006-5725.2025.01.001

Abstract

Abstract:

Kidney disease constitutes a significant global public health issue， with its associated healthcare burden escalating annually. Lipid metabolism disorders play a crucial role in the onset and progression of various kidney diseases. Given the diversity of lipid species and the complexity of metabolic pathways， traditional research methods often fall short in fully elucidating the intricate roles of lipids in kidney diseases. In this context， lipidomics， the systematic analysis of lipid molecules and their metabolic alterations in biological samples， emerges as a powerful tool with unique research value and clinical potential. This review summarizes the latest findings in lipidomics across various kidney diseases and discusses the challenges encountered in clinical application and future research directions.

Key words: diabetic nephropathy, chronic kidney disease, acute kidney injury, lipidomics, biomarkers, pathogenesis

CLC Number:

R692

Jiahui WANG,Ke ZHENG,Xuemei LI. Applications and advances of lipidomics in kidney disease[J]. The Journal of Practical Medicine, 2025, 41(1): 1-6.

Figures/Tables 1

References 53

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方法	优点	缺点
核磁共振(NMR)	与同位素标记联合使用,可以确定同位素标记的核在分子中的具体位置和相对丰度	灵敏度低；所需样本量大
直接注入法（Shot gun）	操作简单方便；多次扫描,结果平均,信噪比高	无色谱分离,不适合分析复杂生物样本
液相色谱质谱法（LC-MS）	高灵敏度；所需样本量小	基质效应；低复现性；成本高
气相色谱质谱法（GC-MS）	高灵敏度；高复现性	样本制备要求高；不适用于热敏感化合物

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Applications and advances of lipidomics in kidney disease

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