环状RNA与动脉粥样硬化性缺血性脑卒中的研究进展

doi:10.3969/j.issn.1006-5725.2024.12.024

Abstract

Abstract:

Stroke is one of the main diseases endangering the health and life of the middle-aged and elderly， and in recent years it shows a younger trend.It has the characteristics of high incidence， mortality and disability rate. Atherosclerosis is the main intervention target for stroke prevention and treatment.CircRNA is highly expressed in the cerebrovascular system and plays an important regulatory role in the pathogenesis of ischemia-reperfusion and ischemic stroke.This paper reviews the mechanism of circRNA and miRNA molecular network in the pathophysiological process of atherosclerosis， ischemic stroke and ischemia-reperfusion injury， so as to provide theoretical support for the application of circRNA in gene diagnosis and drug treatment of atherosclerotic ischemic stroke.

Key words: circRNA, ischemic stroke, atherosclerotic, pathophysiological process, prognosis, biomarkers

CLC Number:

R743.3

Chunling PAN,Xueli YI,Li SU,Shengshan YUAN,Guijiang WEI. Research progress of circrna and atherosclerotic ischemic stroke[J]. The Journal of Practical Medicine, 2024, 40(12): 1755-1761.

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