小而密低密度脂蛋白胆固醇、CXC型趋化因子配体12与糖尿病患者并发心血管疾病的相关性

doi:10.3969/j.issn.1006-5725.2023.22.016

Abstract

Abstract:

Objective To investigate the correlation between serum levels of small dense low density lipoprotein-cholesterol （sdLDL-C） and chemokine CXC motifligand12 （CXCL12） and diabetes mellitus with cardiovascular disease（CVD）. Methods A total of 256 diabetic patients treated in our hospital between June 2021 and September 2022 were selected as the diabetic group. The patients were grouped according to whether they had combined CVD or not. And the serum sdLDL-C as well as CXCL12 levels of each group were compared with healthy volunteers. Risk factors for the complication of CVD in diabetic patients were analyzed. To analyze the diagnostic value of sdLDL-C， CXCL12 and combined test for diabetic patients with complicated CVD. Results Serum sdLDL-C and CXCL12 levels were higher in the diabetes group than in the control group （P < 0.05）. The duration of disease， BMI， LDL-C， and serum sdLDL-C and CXCL12 levels were higher in the cardiovascular disease group than in the non-cardiovascular disease group （P < 0.05）. A multifactorial logistic regression analysis showed that sdLDL-C and CXCL12 were independent risk factors for the complication of CVD in diabetic patients （P < 0.05）. The sensitivity and specificity of serum sdLDL-C and CXCL12 combined test were higher than that of single test. Conclusion Elevated serum sdLDL-C and CXCL12 levels in patients with diabetes mellitus are independent risk factors for the complication of CVD， and the combination of these two tests has a high diagnostic value for diabetes mellitus with CVD.

Key words: diabetes, small dense low-density lipoprotein cholesterol, chemokine CXC motif ligand12, atherosclerotic cardiovascular disease

CLC Number:

R587.1

Li′na MA,Zhenhua CAO,Bing. YANG. Correlation between sdLDL⁃C， CXCL12 and CVD in diabetic patients[J]. The Journal of Practical Medicine, 2023, 39(22): 2953-2957.

Figures/Tables 5

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Fig.1

References 21

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组别	例数	sdLDL-C（mmol/L）	CXCL12（ng/mL）
对照组	40	0.76 ± 0.18	7.15 ± 1.36
糖尿病组	256	1.36 ± 0.23	13.67 ± 2.54
t值		15.754	15.867
P值		< 0.001	< 0.001

组别	例数	性别（男/女）	年龄（岁）	病程（年）	BMI（kg/m²）	吸烟史［例（%）］
非心血管疾病组	138	73/65	57.00 ± 8.72	7.49 ± 2.18	21.83 ± 2.26	64（46.38）
心血管疾病组	118	68/50	58.69 ± 8.98	8.53 ± 3.15	23.18 ± 2.42	68（57.63）
χ²/t值		0.575	1.525	3.105	4.611	3.224
P值		0.448	0.129	0.002	< 0.001	0.073

变量	β	SE	Wald χ²	P值	OR	95%CI
BMI	0.521	0.216	5.818	0.116	1.684	1.103 ~ 2.571
LDL-C	0.687	0.301	5.209	0.082	1.988	1.102 ~ 3.586
sdLDL-C	0.987	0.392	6.340	0.012	2.683	1.244 ~ 5.785
CXCL12	0.694	0.274	6.415	0.011	2.002	1.170 ~ 3.425
常数项	0.251	0.118	4.525	0.033	1.285	-

指标	AUC	Cut?off值	95%CI	敏感度（%）	特异度（%）	约登指数（%）
sdLDL-C	0.824	1.41 mmol/L	0.723 ~ 0.929	86.00	80.00	66.00
CXCL12	0.725	13.96 ng/mL	0.614 ~ 0.835	70.00	92.00	62.00
联合检测	0.921	--	0.814 ~ 0.986	95.00	94.00	88.00

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Correlation between sdLDL⁃C， CXCL12 and CVD in diabetic patients

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