Abstract:

Objective To analyze the predictive value of tumor infiltrating lymphocytes（TILs）in patients with different subtypes of breast cancer treated with neoadjuvant chemotherapy. Methods The clinicopathological data of 56 female patients who underwent neoadjuvant chemotherapy in our hospital from July 2019 to July 2020 were analyzed. The proportion of TILs in the punctured tissue before chemotherapy was calculated and divided into low，medium，and high groups. Postoperative pathological assessment of the chemotherapy response of gross tumor tissues and statistical analysis were performed. Results The total effective rate of neoadjuvant chemotherapy was 76.8%（43/56），the effective rate of neoadjuvant chemotherapy in high TILs proportion group was higher than that in the low TILs proportion group（P < 0.05），and the TILs rate of triple negative breast cancer patients was signifi⁃ cantly higher than that of Luminal type and HER⁃2 positive breast cancer（P < 0.05）. Multivariate analysis showed that the efficacy of neoadjuvant chemotherapy was only related to TILs ratio，but not to age，HR state，HER ⁃2 state and Ki ⁃67 index. Conclusions TILs proportion is an independent predictor for the efficacy of neoadjuvant chemotherapy in breast cancer. A high proportion of TILs indicates a better therapeutic effect，which is more obvi⁃ ous in patients with triple⁃negative breast cancer.

Key words:

tumor infiltrating lymphocytes, breast tumor, neoadjuvant chemotherapy, response to chemotherapy