Abstract:

Objective To observe the correlation between serum microRNA⁃146a（miR⁃146a）and miR⁃ 195 levels and the effect of laser treatment in patients with diabetic retinopathy（DR）. Methods 111 patients with DR admitted to our hospital from January 2018 to January 2020 were selected as the research subjects. The serum levels of miR⁃146a and miR⁃195 were detected before treatment，and laser treatment was performed. Evaluated the effect of laser treatment，analyzed the correlation between serum miR⁃146a and miR⁃195 levels and the effect of laser treatment in DR patients. Results Among 223 DR patients after laser treatment，181 cases were effective and 42 cases were ineffective；after preliminary comparing the data of the ineffective group and the effective group by Logistic regression analysis，the results showed that hypertension，pre⁃treatment serum miR⁃146a and miR⁃195 levels in DR patients were the influencing factors of laser treatment ineffectiveness（OR > 1，P < 0.05）；the receiver operating characteristic curve（ROC）was drawn and found that the pre⁃treatment serum miR⁃146a and miR⁃195 levels single predicted and combined predicted area under the curve（AUC）of laser treatment failure were both > 0.80，with certain predictive performance. Conclusion Serum miR⁃146a and miR⁃195 can be used as predictive indexes of ineffective laser treatment in DR patients. 

Key words:

diabetic retinopathy, microRNA ? 146a, microRNA ? 195, laser, blood glucose, hypertension