Abstract:

Objective To investigate the clinical value of neutrophil lymphocyte ratio（NLR）in criticallyill patients with acute renal injury（AKI）. Methods A total of 405 patients in intensive care unit of the FirstAffiliated Hospital of South China University from January 1，2016 to December 31，2016 were enrolled. AKI wasdiagnosed according to the KDIGO criteria. The correlation of NLR with the development of AKI ，the kidney recoveryand the hospital mortality was analyzed. Results A total of 202 patients were diagnosed with AKI. There weresignificant differences between AKI and non⁃AKI groups in terms of sex，age，basic creatinine，urea nitrogen，CRRT，albumin，triglyceride，procalcitonin，cystatin C and NLR（P < 0.05）. Further analysis of the prognosis ofAKI patients showed that 139 cases survived，including 92 cases of renal function recovery and 47 non⁃recoverycases . There was no significant difference in NLR between the two groups at the admission to ICU and when serumcreatinine the highest. However，NLR significantly decreased in patients with renal function recovery when leavingICU. Logistic regression suggested that NLR was the independent predictor of AKI（OR = 1.213，95% CI 1.155 ~1.274，P < 0.001）. ROC curve showed that the AUC of NLR for predicting AKI and hospital⁃mortality were 0.794（95% CI 0.749 ~ 0.838，P < 0.001）and 0.588，（95%CI：0.517 ~ 0.658，P = 0.017）respectively. The cutoff valuewas 13.4 and 12.2 respectively. Conclusion A higher level of NLR is associated with the development and progno⁃sis of AKI.

Key words: neutrophil lymphocyte ratio, acute kidney injury, critically ill patients