Abstract:

Objective To investigate the clinical efficacy of Bifidobacterium triple viable powder as add⁃ on therapy in children with tic disorder and its effect on the level of excitatory amino acids in serum. Methods A total of 130 children with tic disorder from November 2019 to June 2020 in Wuxi Children′s Hospital were recruited and were randomly divided into tiapride + Bifidobacterium group（n = 50），tiapride group（n = 50） and Bifidobacterium group（n = 30）. The efficacy of Yale Global Tic Severity Scale（YGTSS），serum glutamic acid（Glu）and aspartic acid（Asp）levels and safety of the three groups were assessed and compared before treat⁃ ment，the 4th week and 12th week after treatment. Results Compared with the data before treatment，the YGTSS scores of all groups were lower at the 4th and 12th week after treatment（P < 0.05），At the 4th week，YGTSS scores of the tiapride + Bifidobacterium group and the tiopride group were lower than that of the Bifidobacterium group （P < 0.05）. At the 12th week，the YGTSS scores of the tiapride + Bifidobacterium group were lower than those of the other two groups（P < 0.05）. The levels of serum Glu and Asp of the three groups were lower than before treatment（P < 0.05），and the tiapride + Bifidobacterium group was lower than those of the other two groups（P < 0.05）. The incidence of adverse reactions was 8% in the tiapride + Bifidobacterium group and 10% in the tiopride group and 0% in the Bifidobacterium group. Conclusion Compared with Bifidobacteria alone，the combination of Bifidobacteria and tiapride has better curative effect，which provides a new method for the diagnosis and treat⁃ ment of tic disorders. 

Key words:

tic disorder, Bifidobacterium triple viable powder, Tiapride, Glutamic acid, Aspar? tic acid