Abstract:

Objective To systematically evaluate the efficacy and safety of xingnaojing injection combined with alteplase for ischemic stroke. Methods By searching CNKI，Wanfang，VIP，CBM，PubMed，The Cochrane Library，Embase，randomized controlled studies on xingnaojing injection combined with alteplase for ischemic stroke were systematically collected.A total of 9 studies were included，involving 1005 patients. Meta ⁃analysis of the included related studies was performed by using RevMan 5.3 software. Results Meta⁃analysis showed that the effective rate of the observation group was higher than that of the control group after treatment. NIHSS degree， NDS degree，Ischemic area，TNF⁃ α，PS，IL⁃8，hs⁃CRP，IL⁃1 and IL⁃6 were lower than those of the control group. MoCA score and ADL score were higher than those of the control group. Meanwhile，the blood flow velocity in basilar artery，middle cerebral artery，anterior cerebral artery，posterior cerebral artery and vertebral artery were higher than those of the control group. Adverse event incidence was not statistically different between the two groups. Conclusion The current evidence showedxingnaojing injection combined with alteplase had better cura⁃ tive effect and safety in patients with cerebral infarction. However，the obtained conclusions needed to be validated by high ⁃ quality multi ⁃ center，double ⁃ blind clinical randomized controlled trials，due to the limited quality and quantity of the included studies.

Key words:

xingnaojing injection, alteplase, ischemic stroke, cognitive function, neurologic func? tion, meta?analysis