The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (22): 2877-2881.doi: 10.3969/j.issn.1006⁃5725.2021.22.010

• Clinical Research • Previous Articles     Next Articles

Effect of progesterone receptor on association between body mass index and prognosis in women with estrogen receptor positive breast cancer

MA Lijun*，XING Jun，LIU Ailan，GAO Jinnan.     

  1. Shanxi Bethune Hos⁃ pital，Shanxi Academy of Medical Sciences，Tongji Shanxi Hospital，the Third Hospital of Shanxi Medical Universi⁃ ty，Taiyuan 030032，China

  • Online:2021-11-25 Published:2021-11-25
  • Contact: GAO Jinnan E⁃mail：709535178@qq.com
  • Supported by:
    山西省卫生健康委员会基金（编号：2019008）

Abstract:


Objective This study aims to explore whether the association between body mass index（BMI） and prognosis of estrogen receptor positive（ER+）breast cancer（BC）varies according to the tumor PR status. Methods We collected a total of 1 036 cases with invasive ductal breast cancer from March 2012 to January 2018 in department of breast surgery of Shanxi Bethune Hospital. Women were stratified according to their BMI（< 24， ≥ 24 kg/m2）. Tumor PR status（PR-，PR+）was evaluated by immunohistochemistry. The differences of clinico⁃ pathological features between the groups with different BMI levels were compared；Kaplan⁃Meier method was used to draw the overall survival（OS）curve of the whole group and the patients stratified by PR with different BMI levels，and log⁃rank test was performed. Univariate and multivariate Cox proportional hazards models were used to analyze the factors affecting OS. Results The median follow ⁃ up period was 4.0 years（2.3 ~ 5.7 years）. There were significant differences in age，histological grade，stage，menstrual status and family history of tumor between BMI < 24 kg/m2 group and BMI ≥ 24 kg/m2 group（P < 0.05）. In the whole group，OS in BMI <24 kg/m2 group was better than that in BMI ≥ 24 kg/m2 group（P = 0.033）. In breast cancer patients with PR ⁃ and ER+，OS in BMI < 24 kg/m2 group was better than that in BMI ≥ 24 kg/m2（P = 0.007）；In breast cancer patients with PR+ and ER+，there was no significant difference in OS between BMI < 24 kg/m2 group and BMI ≥ 24 kg/m2 group（P 0.466）. Univariate Cox regression analysis showed that BMI，PR，stage and menstrual status were associated with OS in ER positive breast cancer patients（P < 0.05）. Multivariate Cox regression analysis showed that BMI ≥ 24 kg/m2 （HR = 1.916，95% CI：1.167 ~ 3.144，P = 0.010）and PR negative（HR = 0.348，95% CI：0.208 ~ 0.583，P < 0.001） were independent risk factors for OS in ER positive breast cancer patients. Conclusion Compared with PR+，ER+ obese breast cancer patients，PR-，ER+ women had poorer survival. It suggests that poorer survival is associated with high BMI among women diagnosed with ER+ BC，which provides reference for the prevention and treatment of breast cancer.


Key words: breast tumor,  , body mass index,  , progesterone receptor,  , prognosis