The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (2): 260-263.doi: 10.3969/j.issn.1006⁃5725.2021.02.025

• Medical Examination and Clinical Diagnosis • Previous Articles     Next Articles

Soluble B7⁃H4 expression and diagnostic value in the patients with systemic lupus erythematosus and dis⁃ease activity

YU Daliang，FU Yanping，LI Lang，CHEN Fei，LI Liusheng，LI Yubin
  

  1. Department of Nephrolo⁃gy，Three Gorges University People′s Hospital，the First People′s Hospital of Yichang，Yichang 443000，China
  • Online:2021-01-25 Published:2021-01-25

Abstract:

Objective To investigate the diagnostic value of soluble B7⁃H4 in the patients with SLE. Methods 60 SLE patients and 20 healthy donors were recruited. Disease activity was assessed by SLEDAI scores. The sB7⁃H4 of serum in SLE and healthy donors were analysed using ELISA，and the correlation between sB7⁃H4 of serum in SLE and disease active parameters was analysed too. Results The sB7⁃H4 in serum of SLE patients ［（65.62 ± 21.02）ng/mL］was significantly higher than healthy controls［（55.4 ± 11.2）ng/mL］（P < 0.05）. The sensitivity and specificity of sB7⁃H4 to diagnose active SLE in the SLE group were 56％and 85％respectively，and the area under ROC curve was 0.65．The mean concentration of sB7⁃H4 level in active disease group［（70.99 ± 19.85）ng/mL］were significantly higher than those in inactive disease group［（59.06 ± 20.89）ng/mL］（P < 0.05）， the sensitivity and specificity of sB7⁃H4 to diagnose active disease in the SLE group were 82％and 56％respectively， the area under ROC curve was 0.687. Conclusion The expression of sB7⁃H4 probably may contribute to the diag⁃ 

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