外泌体在骨关节炎诊断和治疗中的现状、机遇与挑战

doi:10.3969/j.issn.1006-5725.2026.16.009

Abstract

Abstract:

Osteoarthritis （OA） is a highly prevalent degenerative joint disease that substantially impairs patients' quality of life. As key mediators of intercellular communication， exosomes have emerged as promising candidates for the diagnosis and therapeutic management of OA owing to their unique biological characteristics. This review summarizes the structural architecture and molecular composition of exosomes， appraises their potential as diagnostic biomarkers for OA， and discusses their translational therapeutic value. We also delineate the current challenges encountered in clinical translation and outline future research directions， with the aim of providing a robust reference for advancing further investigation and clinical translation of exosome-based strategies in the OA research field.

Key words: osteoarthritis, exosomes, diagnosis, treatment

CLC Number:

R684.3

Xiaofei Zhang, Kang Xu, Xun Sun. The current status， opportunities and challenges of exosomes in the diagnosis and treatment of osteoarthritis[J]. The Journal of Practical Medicine, 2026, 42(16): 2937-2944.

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The current status， opportunities and challenges of exosomes in the diagnosis and treatment of osteoarthritis

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